cGMP-Dependent Protein Kinase Encoded by foraging Regulates Motor Axon Guidance in Drosophila by Suppressing Lola Function
文献类型：期刊论文
| 作者 | Peng, Qionglin1,2; Wang, Yijin1,2,4,5; Li, Meixia1; Yuan, Deliang1,2; Xu, Mengbo1; Li, Changqing1; Gong, Zhefeng1,6; Jiao, Renjie1; Liu, Li1,2,3
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| 刊名 | JOURNAL OF NEUROSCIENCE
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| 出版日期 | 2016-04-20 |
| 卷号 | 36期号:16页码:4635-4646 |
| 关键词 | Drosophila Lola motor axon guidance PKG |
| ISSN号 | 0270-6474 |
| 英文摘要 | Correct pathfinding and target recognition of a developing axon are exquisitely regulated processes that require multiple guidance factors. Among these factors, the second messengers, cAMP and cGMP, are known to be involved in establishing the guidance cues for axon growth through different intracellular signaling pathways. However, whether and how cGMP-dependent protein kinase (PKG) regulates axon guidance remains poorly understood. Here, we show that the motor axons of intersegmental nerve b (ISNb) in the Drosophila embryo display targeting defects during axon development in the absence of foraging (for), a gene encoding PKG. In vivo tag expression revealed PKG to be present in the ventral nerve code at late embryonic stages, supporting its function in embryonic axon guidance. Mechanistic studies showed that the transcription factor longitudinal lacking (lola) genetically interacts with for. PKG physically associates with the LolaT isoform via the C-terminal zinc-finger-containing domain. Overexpression of PKG leads to the cytoplasmic retention of LolaT in S2 cells, suggesting a role for PKG in mediating the nucleocytoplasmic trafficking of Lola. Together, these findings reveal a novel function of PKG in regulating the establishment of neuronal connectivity by sequestering Lola in the cytoplasm. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Neurosciences |
| 研究领域[WOS] | Neurosciences & Neurology |
| 关键词[WOS] | GUANYLYL CYCLASE GYC76C ; TRANSCRIPTION FACTOR ; MELANOGASTER ; GROWTH ; RECEPTOR ; GENE ; CONNECTIVITY ; POLYMORPHISM ; EXPRESSION ; REPULSION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000375130000021 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/19980]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China 3.Chinese Acad Sci, Key Lab Mental Hlth, Beijing 100101, Peoples R China 4.Univ Calif Santa Barbara, Neurosci Res Inst, Santa Barbara, CA 93106 USA 5.Univ Calif Santa Barbara, Dept Mol Cellular & Dev Biol, Santa Barbara, CA 93106 USA 6.Zhejiang Univ, Sch Med, Dept Neurobiol, Hangzhou 310058, Zhejiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Peng, Qionglin,Wang, Yijin,Li, Meixia,et al. cGMP-Dependent Protein Kinase Encoded by foraging Regulates Motor Axon Guidance in Drosophila by Suppressing Lola Function[J]. JOURNAL OF NEUROSCIENCE,2016,36(16):4635-4646. |
| APA | Peng, Qionglin.,Wang, Yijin.,Li, Meixia.,Yuan, Deliang.,Xu, Mengbo.,...&Liu, Li.(2016).cGMP-Dependent Protein Kinase Encoded by foraging Regulates Motor Axon Guidance in Drosophila by Suppressing Lola Function.JOURNAL OF NEUROSCIENCE,36(16),4635-4646. |
| MLA | Peng, Qionglin,et al."cGMP-Dependent Protein Kinase Encoded by foraging Regulates Motor Axon Guidance in Drosophila by Suppressing Lola Function".JOURNAL OF NEUROSCIENCE 36.16(2016):4635-4646. |
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来源：心理研究所
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