Genetic and Environmental Contributions to Functional Connectivity Architecture of the Human Brain
文献类型：期刊论文
| 作者 | Yang, Zhi1,2,3 ; Zuo, Xi-Nian1,2; McMahon, Katie L.4; Craddock, R. Cameron5,6; Kelly, Clare7; de Zubicaray, Greig I.8; Hickie, Ian9; Bandettini, Peter A.3; Castellanos, F. Xavier7; Milham, Michael P.5,6
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| 刊名 | CEREBRAL CORTEX
 |
| 出版日期 | 2016-05-01 |
| 卷号 | 26期号:5页码:2341-2352 |
| 关键词 | connectome environmental contribution heritability intrinsic connectivity network twins |
| ISSN号 | 1047-3211 |
| 英文摘要 | One of the grand challenges faced by neuroscience is to delineate the determinants of interindividual variation in the comprehensive structural and functional connection matrices that comprise the human connectome. At present, this endeavor appears most tractable at the macroanatomic scale, where intrinsic brain activity exhibits robust patterns of synchrony that recapitulate core functional circuits at the individual level. Here, we use a classical twin study design to examine the heritability of intrinsic functional network properties in 101 twin pairs, including network activity (i.e., variance of a network's specific temporal fluctuations) and internetwork coherence (i.e., correlation between networks' specific temporal fluctuations). Five of 7 networks exhibited significantly heritable (23.3-65.2%) network activity, 6 of the 21 internetwork coherences were significantly heritable (25.6-42.0%), and 11 of the 21 internetwork coherences were significantly influenced by common environmental factors (18.0-47.1%). These results suggest that the source of interindividual variation in functional connectome has a modular architecture: individual modules represented by intrinsic connectivity networks are genetic controlled, while environmental factors influence the interplays between the modules. This work further provides network-specific hypotheses for discovery of the specific genetic and environmental factors influencing functional specialization and integration of the human brain. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Neurosciences |
| 研究领域[WOS] | Neurosciences & Neurology |
| 关键词[WOS] | HUMAN CEREBRAL-CORTEX ; RESTING-STATE FMRI ; INDEPENDENT COMPONENT ANALYSIS ; SURFACE-BASED ANALYSIS ; DEFAULT MODE NETWORK ; WORKING-MEMORY ; LIFE-SPAN ; PREFRONTAL CORTEX ; GEOMETRICALLY ACCURATE ; MRI |
| 收录类别 | SCI ; SSCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000377469500040 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/19952]  |
| 专题 | 心理研究所_中国科学院行为科学重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Inst Psychol, MRI Res Ctr, Beijing 100101, Peoples R China 3.NIMH, Sect Funct Imaging Methods, Lab Brain & Cognit, NIH, Bethesda, MD 20892 USA 4.Univ Queensland, Ctr Adv Imaging, Brisbane, Qld, Australia 5.Child Mind Inst, New York, NY USA 6.Nathan S Kline Inst Psychiat Res, Orangeburg, NY 10962 USA 7.NYU, Ctr Child Study, Phyllis Green & Randolph Cowen Inst Pediat Neuros, New York, NY USA 8.Univ Queensland, Sch Psychol, Brisbane, Qld, Australia 9.Univ Sydney, Brain & Mind Res Inst, Sydney, NSW 2006, Australia 10.Queensland Inst Med Res, Genet Epidemiol Lab, Brisbane, Qld 4006, Australia |
| 推荐引用方式 GB/T 7714 | Yang, Zhi,Zuo, Xi-Nian,McMahon, Katie L.,et al. Genetic and Environmental Contributions to Functional Connectivity Architecture of the Human Brain[J]. CEREBRAL CORTEX,2016,26(5):2341-2352. |
| APA | Yang, Zhi.,Zuo, Xi-Nian.,McMahon, Katie L..,Craddock, R. Cameron.,Kelly, Clare.,...&Wright, Margaret J..(2016).Genetic and Environmental Contributions to Functional Connectivity Architecture of the Human Brain.CEREBRAL CORTEX,26(5),2341-2352. |
| MLA | Yang, Zhi,et al."Genetic and Environmental Contributions to Functional Connectivity Architecture of the Human Brain".CEREBRAL CORTEX 26.5(2016):2341-2352. |
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来源：心理研究所
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