Copper-catalyzed fluorination of 2-pyridyl aryl bromides
文献类型：期刊论文
| 作者 | Mu X(慕欣); Zhang H(张浩); Chen PH(陈品红); Liu GS(刘国生) |
| 刊名 | Chem. Sci.
 |
| 出版日期 | 2014 |
| 卷号 | 5期号:1页码:275-280 |
| 其他题名 | 铜催化2-吡啶基芳基溴的氟化反应 |
| 通讯作者 | 刘国生 |
| 英文摘要 | Copper(I)-catalyzed cross-coupling of aryl halides is the subject of extensive interest in synthetic chemistry, but the related catalytic fluorination is unsuccessful. Herein, we have developed a novel copper-catalyzed fluorination of aryl bromides using AgF as the fluorine source. In this transformation a pyridyl directing group is essential for successful catalytic fluorination. A XANES/EXAFS study indicated that the presence of the pyridyl group is essential to stabilize the Cu(I) species and accelerate oxidative addition of the aryl bromide. Further mechanistic studies implicated a Cu(I/III) catalytic cycle in this Cu(I)-catalyzed fluorination, and final aryl C-F bond formation possibly proceeds through an irreversible reductive elimination of the ArCu(III)-F species. This rare report of catalytic fluorination by a copper catalyst provides a valuable foundation for further development of Cu(I)-catalyzed fluorination of aryl halides. |
| 学科主题 | 金属有机化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1039/c3sc51876k |
| 语种 | 英语 |
| 源URL | [http://ir.sioc.ac.cn/handle/331003/38996]  |
| 专题 | 上海有机化学研究所_金属有机化学国家重点实验室 |
| 作者单位 | 中国科学院上海有机化学研究所, 金属有机化学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Mu X,Zhang H,Chen PH,et al. Copper-catalyzed fluorination of 2-pyridyl aryl bromides[J]. Chem. Sci.,2014,5(1):275-280. |
| APA | 慕欣,张浩,陈品红,&刘国生.(2014).Copper-catalyzed fluorination of 2-pyridyl aryl bromides.Chem. Sci.,5(1),275-280. |
| MLA | 慕欣,et al."Copper-catalyzed fluorination of 2-pyridyl aryl bromides".Chem. Sci. 5.1(2014):275-280. |
入库方式： OAI收割
来源：上海有机化学研究所
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