SpinPhox/Iridium(I)-Catalyzed Asymmetric Hydrogenation of Cyclic alpha-Alkylidene Carbonyl Compounds
文献类型：期刊论文
| 作者 | Liu X(刘旭); Han ZB(韩召斌); Wang Z(王正); Ding KL(丁奎岭) |
| 刊名 | Angew. Chem.-Int. Edit.
 |
| 出版日期 | 2014 |
| 卷号 | 53期号:7页码:1978-1982 |
| 其他题名 | SpinPhox/铱(I)催化环状alpha-亚烷基羰基化合物的不对称氢化 |
| 通讯作者 | 丁奎岭 |
| 英文摘要 | Optically active medium-sized cyclic carbonyl compounds bearing an -chiral carbon center are of interest in pharmaceutical sciences and asymmetric synthesis. Herein, SpinPhox/Ir-I catalysts have been demonstrated to be highly enantioselective in the asymmetric hydrogenation of the CC bonds in the exocyclic ,-unsaturated cyclic carbonyls, including a broad range of -alkylidene lactams, unsaturated cyclic ketones, and lactones. It is noteworthy that the procedure can be successfully used in the asymmetric hydrogenation of the challenging -alkylidenelactam substrates with six- or seven-membered rings, thus affording the corresponding optically active carbonyl compounds with an -chiral carbon center in generally excellent enantiomeric excesses (up to 98%ee). Synthetic utility of the protocol has also been demonstrated in the asymmetric synthesis of the anti-inflammatory drug loxoprofen and its analogue, as well as biologically important epsilon-aminocaproic acid derivatives. |
| 学科主题 | 金属有机化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1002/anie.201309521 |
| 语种 | 英语 |
| 源URL | [http://ir.sioc.ac.cn/handle/331003/38998]  |
| 专题 | 上海有机化学研究所_金属有机化学国家重点实验室 |
| 作者单位 | 中科院上海有机化学研究所 |
| 推荐引用方式 GB/T 7714 | Liu X,Han ZB,Wang Z,et al. SpinPhox/Iridium(I)-Catalyzed Asymmetric Hydrogenation of Cyclic alpha-Alkylidene Carbonyl Compounds[J]. Angew. Chem.-Int. Edit.,2014,53(7):1978-1982. |
| APA | 刘旭,韩召斌,王正,&丁奎岭.(2014).SpinPhox/Iridium(I)-Catalyzed Asymmetric Hydrogenation of Cyclic alpha-Alkylidene Carbonyl Compounds.Angew. Chem.-Int. Edit.,53(7),1978-1982. |
| MLA | 刘旭,et al."SpinPhox/Iridium(I)-Catalyzed Asymmetric Hydrogenation of Cyclic alpha-Alkylidene Carbonyl Compounds".Angew. Chem.-Int. Edit. 53.7(2014):1978-1982. |
入库方式： OAI收割
来源：上海有机化学研究所
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