Enantioselective Double Manipulation of Tetrahydroisoquinolines with Terminal Alkynes and Aldehydes under Copper(I) Catalysis
文献类型：期刊论文
| 作者 | Lin WL(林渭龙)1; Cao T(曹陶)1; Fan W(范武)1; Han YL(韩玉林)1; Kuang JQ(况锦强)1; Luo HW(罗鸿文)1; 缪不可言1; Tang XJ(汤鑫军)1; Yu Q(俞琼)1; Yuan WM(袁伟民)1 |
| 刊名 | Angew. Chem.-Int. Edit.
 |
| 出版日期 | 2014 |
| 卷号 | 53期号:1页码:277-281 |
| 其他题名 | 铜(I)催化的对映选择性的四氢异喹啉、末端炔和醛的反应 |
| 通讯作者 | 麻生明 |
| 英文摘要 | Tetrahydroisoquinoline alkaloids with a C1 stereogenic center are a common unit in many natural and non-natural compounds of biological importance. Herein we describe a novel Cu-I-catalyzed highly chemo- and enantioselective synthesis of chiral tetrahydroisoquinoline-alkaloid derivatives from readily available unsubstituted tetrahydroisoquinolines, aldehydes, and terminal alkynes in the presence of the ligand (R,R)-N-pinap. This synthetic operation installs two substituents in the 1- and 2-positions. |
| 学科主题 | 金属有机化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1002/anie.201308699 |
| 语种 | 英语 |
| 源URL | [http://ir.sioc.ac.cn/handle/331003/39010]  |
| 专题 | 上海有机化学研究所_金属有机化学国家重点实验室 |
| 作者单位 | 1.中科院上海有机化学研究所 2.华东师范大学 |
| 推荐引用方式 GB/T 7714 | Lin WL,Cao T,Fan W,et al. Enantioselective Double Manipulation of Tetrahydroisoquinolines with Terminal Alkynes and Aldehydes under Copper(I) Catalysis[J]. Angew. Chem.-Int. Edit.,2014,53(1):277-281. |
| APA | 林渭龙.,曹陶.,范武.,韩玉林.,况锦强.,...&麻生明.(2014).Enantioselective Double Manipulation of Tetrahydroisoquinolines with Terminal Alkynes and Aldehydes under Copper(I) Catalysis.Angew. Chem.-Int. Edit.,53(1),277-281. |
| MLA | 林渭龙,et al."Enantioselective Double Manipulation of Tetrahydroisoquinolines with Terminal Alkynes and Aldehydes under Copper(I) Catalysis".Angew. Chem.-Int. Edit. 53.1(2014):277-281. |
入库方式： OAI收割
来源：上海有机化学研究所
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