Kinetic Resolution of 2-Substituted 2,3-Dihydro-4-pyridones by Palladium-Catalyzed Asymmetric Allylic Alkylation: Catalytic Asymmetric Total Synthesis of Indolizidine (-)-209I
文献类型：期刊论文
| 作者 | Lei BL(雷柏林); Zhang QS(张卿菘); Yu WH(余伟华); Ding QP(丁秋平); Ding CH(丁昌华); Hou XL(侯雪龙) |
| 刊名 | Org. Lett.
 |
| 出版日期 | 2014 |
| 卷号 | 16期号:7页码:1944-1947 |
| 其他题名 | 钯催化烯丙基取代反应对2-取代-2,3-二氢哌啶酮的动力学拆分: Indizidine (-)-209I 的催化不对称全合成 |
| 通讯作者 | 丁昌华 ; 侯雪龙 |
| 英文摘要 | The kinetic resolution of 2-substituted-2,3-dihydro-4-pyridones was realized via a Pd-catalyzed allylic substitution reaction using a commercially available (S)-P-Phos as a ligand, affording optically active dihydropyridones and C-allylated dihydropyridones in high yields and good enantioselectivities with the S-factor up to 43. With this protocol, a catalytic asymmetric total synthesis of indolizidine (-)-209I was realized for the first time. |
| 学科主题 | 金属有机化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1021/ol500498m |
| 语种 | 英语 |
| 源URL | [http://ir.sioc.ac.cn/handle/331003/39050]  |
| 专题 | 上海有机化学研究所_金属有机化学国家重点实验室 |
| 作者单位 | 中科院上海有机化学研究所 |
| 推荐引用方式 GB/T 7714 | Lei BL,Zhang QS,Yu WH,et al. Kinetic Resolution of 2-Substituted 2,3-Dihydro-4-pyridones by Palladium-Catalyzed Asymmetric Allylic Alkylation: Catalytic Asymmetric Total Synthesis of Indolizidine (-)-209I[J]. Org. Lett.,2014,16(7):1944-1947. |
| APA | 雷柏林,张卿菘,余伟华,丁秋平,丁昌华,&侯雪龙.(2014).Kinetic Resolution of 2-Substituted 2,3-Dihydro-4-pyridones by Palladium-Catalyzed Asymmetric Allylic Alkylation: Catalytic Asymmetric Total Synthesis of Indolizidine (-)-209I.Org. Lett.,16(7),1944-1947. |
| MLA | 雷柏林,et al."Kinetic Resolution of 2-Substituted 2,3-Dihydro-4-pyridones by Palladium-Catalyzed Asymmetric Allylic Alkylation: Catalytic Asymmetric Total Synthesis of Indolizidine (-)-209I".Org. Lett. 16.7(2014):1944-1947. |
入库方式： OAI收割
来源：上海有机化学研究所
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