Automated Modular Synthesis of Aptamer-Drug Conjugates for Targeted Drug Delivery
文献类型：期刊论文
| 作者 | Wang RW(王若文)1; ZHU GUIZHI1; MEI LEI1; XIE YAN1; MA HAIBIN1; YE MAO1; Qing FL(卿凤翎)1; Tan YH(谭蔚泓)1 |
| 刊名 | J. Am. Chem. Soc.
 |
| 出版日期 | 2014 |
| 卷号 | 136期号:7页码:2731-2734 |
| 其他题名 | 为靶向药物传递的适体偶联药物的自动模块化合成 |
| 通讯作者 | 谭蔚泓 |
| 英文摘要 | Aptamer-drug conjugates (ApDCs) are promising targeted drug delivery systems for reducing toxicity while increasing the efficacy of chemotherapy. However, current ApDC technologies suffer from problems caused by the complicated preparation and low controllability of drug aptamer conjugation. To solve such problems, we have designed and synthesized a therapeutic module for solid phase synthesis, which is a phosphoramdite containing an anticancer drug moiety and a photocleavable linker. Using this module, we have realized automated and modular synthesis of ApDCs, and multiple drugs were efficiently incorporated into ApDCs at predesigned positions. The ApDCs not only recognize target cancer cells specifically, but also release drugs in a photocontrollable manner. We demonstrated the potential of automated and modular ApDC technology for applications in targeted cancer therapy. |
| 学科主题 | 有机化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1021/ja4117395 |
| 语种 | 英语 |
| 源URL | [http://ir.sioc.ac.cn/handle/331003/39154]  |
| 专题 | 上海有机化学研究所_上海有机化学研究所 |
| 作者单位 | 1.湖南大学 2.中科院上海有机化学研究所 |
| 推荐引用方式 GB/T 7714 | Wang RW,ZHU GUIZHI,MEI LEI,et al. Automated Modular Synthesis of Aptamer-Drug Conjugates for Targeted Drug Delivery[J]. J. Am. Chem. Soc.,2014,136(7):2731-2734. |
| APA | 王若文.,ZHU GUIZHI.,MEI LEI.,XIE YAN.,MA HAIBIN.,...&谭蔚泓.(2014).Automated Modular Synthesis of Aptamer-Drug Conjugates for Targeted Drug Delivery.J. Am. Chem. Soc.,136(7),2731-2734. |
| MLA | 王若文,et al."Automated Modular Synthesis of Aptamer-Drug Conjugates for Targeted Drug Delivery".J. Am. Chem. Soc. 136.7(2014):2731-2734. |
入库方式： OAI收割
来源：上海有机化学研究所
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