Enhancement of Neighbouring-Group Participation in Cu-0-Promoted Cross-Coupling gem-Difluoromethylenation of Aryl/Alkenyl Halides with 1,3-Azolic Difluoromethyl Bromides
文献类型：期刊论文
| 作者 | Jiang HZ(蒋海珍)1; LU WENJUN1; YANG KUN1; MA GUOBIN1; XU MINJUN1; Li J(李佳)1; Yao JH(姚建华)1; WAN WEN1; DENG HONGMEI1; WU SHAOXIONG1 |
| 刊名 | Chem.-Eur. J.
 |
| 出版日期 | 2014 |
| 卷号 | 20期号:32页码:10084-10092 |
| 其他题名 | 铜催化gem-Difluoromethylenation的不饱和卤化物和1,3-Azolic Difluoromethyl Bromides的交叉耦合反应中的邻位增强作用 |
| 通讯作者 | 蒋海珍 ; 朱仕正 ; HAO JIAN |
| 英文摘要 | A copper(0)-promoted direct reductive gem-difluoromethylenation of unactivated aryl or alkenyl halides with benzo-1,3-azolic (oxa-, thia- or aza-) difluoromethyl bromides or 2-bromodifluoromethyl-1,3-oxazoline has been developed for the construction of pharmaceutically important gem-difluoromethylene-linked twin molecules. The unique p-conjugated aryl-fused 1,3-azolic moiety in difluoromethyl bromide substrates could stabilise the reaction intermediates, which promotes the reactivities, providing facile access to the cross-coupling products in good to excellent yields, and allowing significant functional group tolerance. The reaction exhibits an enhanced neighbouring-group-participation effect. This method could provide a new strategy for the construction of gem-difluoromethylene-linked identical or nonidentical twin drugs through further functionalisation of 1,3-azolic skeletons. |
| 学科主题 | 有机化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1002/chem.201402205 |
| 语种 | 英语 |
| 源URL | [http://ir.sioc.ac.cn/handle/331003/39165]  |
| 专题 | 上海有机化学研究所_上海有机化学研究所 |
| 作者单位 | 1.上海大学 2.中科院上海有机化学研究所 3.美国艾默里大学 |
| 推荐引用方式 GB/T 7714 | Jiang HZ,LU WENJUN,YANG KUN,et al. Enhancement of Neighbouring-Group Participation in Cu-0-Promoted Cross-Coupling gem-Difluoromethylenation of Aryl/Alkenyl Halides with 1,3-Azolic Difluoromethyl Bromides[J]. Chem.-Eur. J.,2014,20(32):10084-10092. |
| APA | 蒋海珍.,LU WENJUN.,YANG KUN.,MA GUOBIN.,XU MINJUN.,...&HAO JIAN.(2014).Enhancement of Neighbouring-Group Participation in Cu-0-Promoted Cross-Coupling gem-Difluoromethylenation of Aryl/Alkenyl Halides with 1,3-Azolic Difluoromethyl Bromides.Chem.-Eur. J.,20(32),10084-10092. |
| MLA | 蒋海珍,et al."Enhancement of Neighbouring-Group Participation in Cu-0-Promoted Cross-Coupling gem-Difluoromethylenation of Aryl/Alkenyl Halides with 1,3-Azolic Difluoromethyl Bromides".Chem.-Eur. J. 20.32(2014):10084-10092. |
入库方式： OAI收割
来源：上海有机化学研究所
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