Characterization of QmnD3/QmnD4 for Double Bond Formation in Quartromicin Biosynthesis
文献类型：期刊论文
| 作者 | Wu LF(吴龙飞); He HY(贺海燕); Pan HX(潘海学); Han L(韩莉); Wang RX(王任小); Tang GL(唐功利) |
| 刊名 | Org. Lett.
 |
| 出版日期 | 2014 |
| 卷号 | 16期号:6页码:1578-1581 |
| 其他题名 | 四重霉素生物合成中发现了QmnD3/QmnD4催化双键形成 |
| 通讯作者 | 唐功利 |
| 英文摘要 | In this work, two enzymes responsible for the biogenesis of possible [4 + 2] reaction precursors in the quartromicin biosynthetic pathway were characterized: acetylation of 1 to yield 2 was catalyzed by QmnD3, and subsequent acetic acid elimination of 2 to form double bond product 3 was catalyzed by QmnD4. Site-directed mutagenesis assay of QmnD3 and QmnD4 was investigated, and a general base-catalyzed mechanism for QmnD4 is proposed. |
| 学科主题 | 生命有机化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1021/ol500111n |
| 语种 | 英语 |
| 源URL | [http://ir.sioc.ac.cn/handle/331003/38940]  |
| 专题 | 上海有机化学研究所_生命有机化学国家重点实验室 |
| 作者单位 | 中科院上海有机化学研究所 |
| 推荐引用方式 GB/T 7714 | Wu LF,He HY,Pan HX,et al. Characterization of QmnD3/QmnD4 for Double Bond Formation in Quartromicin Biosynthesis[J]. Org. Lett.,2014,16(6):1578-1581. |
| APA | 吴龙飞,贺海燕,潘海学,韩莉,王任小,&唐功利.(2014).Characterization of QmnD3/QmnD4 for Double Bond Formation in Quartromicin Biosynthesis.Org. Lett.,16(6),1578-1581. |
| MLA | 吴龙飞,et al."Characterization of QmnD3/QmnD4 for Double Bond Formation in Quartromicin Biosynthesis".Org. Lett. 16.6(2014):1578-1581. |
入库方式： OAI收割
来源：上海有机化学研究所
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