Unified flexible total synthesis of chlorofusin and artificial Click mimics as antagonists against p53-HDM2 interactions
文献类型：期刊论文
| 作者 | Qiu HB(邱海波); Chen XY(陈新雅); Li Q(李晴); Qian WJ(钱文建); Yu SM(于顺明); Tang GL(唐功利); Yao ZJ(姚祝军) |
| 刊名 | Tetrahedron Lett.
 |
| 出版日期 | 2014 |
| 卷号 | 55期号:44页码:6055-6059 |
| 其他题名 | Unified flexible total synthesis of chlorofusin and artificial Click mimics as antagonists against p53-HDM2 interactions |
| 通讯作者 | 唐功利 ; 姚祝军 |
| 英文摘要 | A practical HPLC-free total synthesis of chlorofusin has been successfully accomplished in this work. The new synthesis showed great flexibility and convenience in generating artificial natural product-like mimics through Click chemistry, and enabled us to further investigate the biological importance of the chromophore and the spiro-aminal functionality of the natural product. The entire skeleton is believed to be essential for satisfactory biological activities of both natural chlorofusin and unnatural mimics. Two artificial Click hybrids were found to exhibit improved inhibitory activity against p53-HDM2 bindings over the natural product. (C) 2014 Elsevier Ltd. All rights reserved. |
| 学科主题 | 生命有机化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1016/j.tetlet.2014.09.028 |
| 语种 | 英语 |
| 源URL | [http://ir.sioc.ac.cn/handle/331003/38958]  |
| 专题 | 上海有机化学研究所_生命有机化学国家重点实验室 |
| 作者单位 | 中科院上海有机化学研究所 |
| 推荐引用方式 GB/T 7714 | Qiu HB,Chen XY,Li Q,et al. Unified flexible total synthesis of chlorofusin and artificial Click mimics as antagonists against p53-HDM2 interactions[J]. Tetrahedron Lett.,2014,55(44):6055-6059. |
| APA | 邱海波.,陈新雅.,李晴.,钱文建.,于顺明.,...&姚祝军.(2014).Unified flexible total synthesis of chlorofusin and artificial Click mimics as antagonists against p53-HDM2 interactions.Tetrahedron Lett.,55(44),6055-6059. |
| MLA | 邱海波,et al."Unified flexible total synthesis of chlorofusin and artificial Click mimics as antagonists against p53-HDM2 interactions".Tetrahedron Lett. 55.44(2014):6055-6059. |
入库方式： OAI收割
来源：上海有机化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。