Copper-Catalyzed Asymmetric Hydroboration of alpha-Dehydroamino Acid Derivatives: Facile Synthesis of Chiral beta-Hydroxy-alpha-amino Acids
文献类型：期刊论文
| 作者 | He ZT(何智涛); Zhao YS(赵一爽); Tian P(田平); Wang CC(王川川); Dong HQ(董汉清); Lin GQ(林国强) |
| 刊名 | Org. Lett.
 |
| 出版日期 | 2014 |
| 卷号 | 16期号:5页码:1426-1429 |
| 其他题名 | Copper-Catalyzed Asymmetric Hydroboration of alpha-Dehydroamino Acid Derivatives: Facile Synthesis of Chiral beta-Hydroxy-alpha-amino Acids |
| 通讯作者 | 田平 ; 林国强 |
| 英文摘要 | The Cu-catalyzed asymmetric conjugate hydroboration reaction of beta-substituted alpha-dehydroamino acid derivatives has been established, affording enantioenriched syn- and anti-beta-boronate-alpha-amino acid derivatives with excellent combined yields (83-99%, dr approximate to 1:1) and excellent enantioselectivities (92-98% ee). The hydroboration products were expediently converted into valuable beta-hydroxy-alpha-amino acid derivatives, which were widely used in the preparation of chiral drugs and bioactive molecules. |
| 学科主题 | 天然产物有机化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1021/ol500219e |
| 语种 | 英语 |
| 源URL | [http://ir.sioc.ac.cn/handle/331003/38974]  |
| 专题 | 上海有机化学研究所_中科院天然产物有机化学重点实验室 |
| 作者单位 | 中科院上海有机化学研究所 |
| 推荐引用方式 GB/T 7714 | He ZT,Zhao YS,Tian P,et al. Copper-Catalyzed Asymmetric Hydroboration of alpha-Dehydroamino Acid Derivatives: Facile Synthesis of Chiral beta-Hydroxy-alpha-amino Acids[J]. Org. Lett.,2014,16(5):1426-1429. |
| APA | 何智涛,赵一爽,田平,王川川,董汉清,&林国强.(2014).Copper-Catalyzed Asymmetric Hydroboration of alpha-Dehydroamino Acid Derivatives: Facile Synthesis of Chiral beta-Hydroxy-alpha-amino Acids.Org. Lett.,16(5),1426-1429. |
| MLA | 何智涛,et al."Copper-Catalyzed Asymmetric Hydroboration of alpha-Dehydroamino Acid Derivatives: Facile Synthesis of Chiral beta-Hydroxy-alpha-amino Acids".Org. Lett. 16.5(2014):1426-1429. |
入库方式： OAI收割
来源：上海有机化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。