Tunable Arylative Cyclization of 1,6-Enynes Triggered by Rhodium(III)-Catalyzed C-H Activation
文献类型：期刊论文
| 作者 | 福井雄树; Liu P(刘平); He ZT(何智涛); Wu NY(吴诺毅); Tian P(田平); Lin GQ(林国强) |
| 刊名 | J. Am. Chem. Soc.
 |
| 出版日期 | 2014 |
| 卷号 | 136期号:44页码:15607-15614 |
| 其他题名 | Tunable Arylative Cyclization of 1,6-Enynes Triggered by Rhodium(III)-Catalyzed C-H Activation |
| 通讯作者 | 田平 ; 林国强 |
| 英文摘要 | Two tunable arylative cyclizations of cyclohexadienone-containing 1,6-enynes are reported via rhodium(III)-catalyzed C-H activation of O-substituted N-hydroxybenzamides. The use of different O substituents, i.e. O-Piv and O-Me, on the directing group allows the formation of either tetracyclic isoquinolones through an (c)-Michael addition process or hydrobenzofurans through a (N)Michael addition process. Mechanistic investigations of these two cascade reactions clearly indicated that the C-H bond cleavage process was involved in the turnover-limiting step. Furthermore, the cyclization products could be subjected to various transformations for elaborating the pharmaceutically and synthetically valuable potential. This is the first example of a rhodium(III)-catalyzed arylative cyclization reaction of 1,6-enynes, and the results extend the application realm of Cp*Rh-III-catalyzed C-H activation cascade reactions. |
| 学科主题 | 天然产物有机化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1021/ja5072702 |
| 语种 | 英语 |
| 源URL | [http://ir.sioc.ac.cn/handle/331003/38993]  |
| 专题 | 上海有机化学研究所_中科院天然产物有机化学重点实验室 |
| 作者单位 | 中科院上海有机化学研究所 |
| 推荐引用方式 GB/T 7714 | 福井雄树,Liu P,He ZT,et al. Tunable Arylative Cyclization of 1,6-Enynes Triggered by Rhodium(III)-Catalyzed C-H Activation[J]. J. Am. Chem. Soc.,2014,136(44):15607-15614. |
| APA | 福井雄树,刘平,何智涛,吴诺毅,田平,&林国强.(2014).Tunable Arylative Cyclization of 1,6-Enynes Triggered by Rhodium(III)-Catalyzed C-H Activation.J. Am. Chem. Soc.,136(44),15607-15614. |
| MLA | 福井雄树,et al."Tunable Arylative Cyclization of 1,6-Enynes Triggered by Rhodium(III)-Catalyzed C-H Activation".J. Am. Chem. Soc. 136.44(2014):15607-15614. |
入库方式： OAI收割
来源：上海有机化学研究所
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