Selective mono?uorination of active methylene compounds: the important role of ZnCl2 in inhibiting over?uorination
文献类型：期刊论文
| 作者 | Jiang FZ(姜範洲); Zhao YC(赵延川); Hu JB(胡金波) |
| 刊名 | Org. Chem. Front.
 |
| 出版日期 | 2014 |
| 卷号 | 1页码:625-629 |
| 其他题名 | 对活泼亚甲基化合物的选择性单氟化: 氯化锌在抑制过渡氟化中的重要作用 |
| 通讯作者 | 胡金波 |
| 英文摘要 | In the presence of zinc chloride (ZnCl2), active methylene compounds can be selectively monofluorinated at room temperature, and the undesired overfluorination (gem-difluorination) can be significantly diminished. The mechanistic study shows that ZnCl2 plays an important role in selective monofluorination through its interaction with a Br?nsted base to control the deprotonation of the starting methylene compounds over the corresponding monofluorinated products. |
| 学科主题 | 氟化学 |
| 原文出处 | http://dx.doi.org/10.1039/c4qo00090k |
| 语种 | 英语 |
| 源URL | [http://ir.sioc.ac.cn/handle/331003/38815]  |
| 专题 | 上海有机化学研究所_中科院有机氟化学重点实验室 |
| 作者单位 | 中科院上海有机化学研究所 |
| 推荐引用方式 GB/T 7714 | Jiang FZ,Zhao YC,Hu JB. Selective mono?uorination of active methylene compounds: the important role of ZnCl2 in inhibiting over?uorination[J]. Org. Chem. Front.,2014,1:625-629. |
| APA | 姜範洲,赵延川,&胡金波.(2014).Selective mono?uorination of active methylene compounds: the important role of ZnCl2 in inhibiting over?uorination.Org. Chem. Front.,1,625-629. |
| MLA | 姜範洲,et al."Selective mono?uorination of active methylene compounds: the important role of ZnCl2 in inhibiting over?uorination".Org. Chem. Front. 1(2014):625-629. |
入库方式： OAI收割
来源：上海有机化学研究所
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