热门
Palladium-Catalyzed Difluoroalkylation of Aryl Boronic Acids: A New Method for the Synthesis of Aryldifluoromethylated Phosphonates and Carboxylic Acid Derivatives
文献类型：期刊论文
| 作者 | Feng Z(冯璋); Min QQ(闵巧桥); Xiao YL(肖玉兰); Zhang B(章博); Zhang XG(张新刚) |
| 刊名 | Angew. Chem.-Int. Edit.
 |
| 出版日期 | 2014 |
| 卷号 | 53期号:6页码:1669-1673 |
| 其他题名 | Pd-催化芳基硼酸的二氟烷基化: 一种合成芳基二氟膦酸酯和芳基二氟羧酸衍生物的新方法 |
| 通讯作者 | 张新刚 |
| 英文摘要 | The palladium-catalyzed difluoroalkylation of aryl boronic acids with bromodifluoromethylphosphonate, bromodifluoroacetate, and further derivatives has been developed. This method provides a facile and useful access to a series of functionalized difluoromethylated arenes (ArCF2PO(OEt)(2), ArCF2CO2Et, and (ArCF2CONRR2)-R-1) that have important applications in drug discovery and development. Preliminary mechanistic studies reveal that a single electron transfer (SET) pathway may be involved in the catalytic cycle. |
| 学科主题 | 氟化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1002/anie.201309535 |
| 语种 | 英语 |
| 源URL | [http://ir.sioc.ac.cn/handle/331003/38873]  |
| 专题 | 上海有机化学研究所_中科院有机氟化学重点实验室 |
| 作者单位 | 中科院上海有机化学研究所 |
| 推荐引用方式 GB/T 7714 | Feng Z,Min QQ,Xiao YL,et al. Palladium-Catalyzed Difluoroalkylation of Aryl Boronic Acids: A New Method for the Synthesis of Aryldifluoromethylated Phosphonates and Carboxylic Acid Derivatives[J]. Angew. Chem.-Int. Edit.,2014,53(6):1669-1673. |
| APA | 冯璋,闵巧桥,肖玉兰,章博,&张新刚.(2014).Palladium-Catalyzed Difluoroalkylation of Aryl Boronic Acids: A New Method for the Synthesis of Aryldifluoromethylated Phosphonates and Carboxylic Acid Derivatives.Angew. Chem.-Int. Edit.,53(6),1669-1673. |
| MLA | 冯璋,et al."Palladium-Catalyzed Difluoroalkylation of Aryl Boronic Acids: A New Method for the Synthesis of Aryldifluoromethylated Phosphonates and Carboxylic Acid Derivatives".Angew. Chem.-Int. Edit. 53.6(2014):1669-1673. |
入库方式： OAI收割
来源：上海有机化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。