Nickel-Catalyzed Cross-Coupling of Functionalized Difluoromethyl Bromides and Chlorides with Aryl Boronic Acids: A General Method for Difluoroalkylated Arenes
文献类型：期刊论文
| 作者 | Xiao YL(肖玉兰); Guo WH(郭文豪); He GZ(何国珍); Pan Q(潘强); Zhang XG(张新刚) |
| 刊名 | Angew. Chem.-Int. Edit.
 |
| 出版日期 | 2014 |
| 卷号 | 53期号:37页码:9909-9913 |
| 其他题名 | 一种通过镍催化下二氟烷基溴、氯对芳基硼酸合成二氟烷基芳烃的通用方法 |
| 通讯作者 | 张新刚 |
| 英文摘要 | Transition-metal-catalyzed difluoroalkylation of aromatics remains challenging despite the importance of difluoroalkylated arenes in medicinal chemistry. Herein, the first successful example of nickel-catalyzed difluoroalkylation of aryl boronic acids is described. The reaction allows access to a variety of functionalized difluoromethyl bromides and chlorides, and paves the way to highly cost-efficient synthesis of a wide range of difluoroalkylated arenes. The notable features of this protocol are its high generality, excellent functional-group compatibility, low-cost nickel-catalyst, and practicality for gram-scale production, thus providing a facile method for applications in drug discovery and development. |
| 学科主题 | 氟化学 |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1002/anie.201405653 |
| 语种 | 英语 |
| 源URL | [http://ir.sioc.ac.cn/handle/331003/38883]  |
| 专题 | 上海有机化学研究所_中科院有机氟化学重点实验室 |
| 作者单位 | 中科院上海有机化学研究所 |
| 推荐引用方式 GB/T 7714 | Xiao YL,Guo WH,He GZ,et al. Nickel-Catalyzed Cross-Coupling of Functionalized Difluoromethyl Bromides and Chlorides with Aryl Boronic Acids: A General Method for Difluoroalkylated Arenes[J]. Angew. Chem.-Int. Edit.,2014,53(37):9909-9913. |
| APA | 肖玉兰,郭文豪,何国珍,潘强,&张新刚.(2014).Nickel-Catalyzed Cross-Coupling of Functionalized Difluoromethyl Bromides and Chlorides with Aryl Boronic Acids: A General Method for Difluoroalkylated Arenes.Angew. Chem.-Int. Edit.,53(37),9909-9913. |
| MLA | 肖玉兰,et al."Nickel-Catalyzed Cross-Coupling of Functionalized Difluoromethyl Bromides and Chlorides with Aryl Boronic Acids: A General Method for Difluoroalkylated Arenes".Angew. Chem.-Int. Edit. 53.37(2014):9909-9913. |
入库方式： OAI收割
来源：上海有机化学研究所
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