A proteomic study on liver impairment in rat pups induced by maternal microcystin-LR exposure
文献类型：期刊论文
| 作者 | Zhao, Sujuan; Xie, Ping; Chen, Jun; Liu, Luyi; Fan, Huihui |
| 刊名 | ENVIRONMENTAL POLLUTION
 |
| 出版日期 | 2016-05-01 |
| 卷号 | 212页码:197-207 |
| 关键词 | MCLR Rat pups Proteomics Liver Oxidative damage |
| ISSN号 | 0269-7491 |
| 英文摘要 | There is mounting evidence indicating that microcystins (MCs) are heptapeptide toxins. Recent studies have also shown that MCLR can transfer from mother to offspring, but it is unclear whether maternal MCLR can influence the liver of offspring or not. In this study, pregnant SD rats were injected intraperitoneally with a saline solution (control) or 10 mu g/kg MCLR per day from gestational day 8 (GD8) to postnatal day 15 (PD15) for a total of 4 weeks. 2-DE and MALDI-TOF-TOF mass spectrometry were used to screen for MCLR target proteins in the livers of rat pups. Our results demonstrated that MCLR could accumulate in the livers of neonatal rats. Proteomics studies also showed that MCLR significantly influenced many proteins, including those involved in the cytoskeleton, metabolism and particularly oxidative stress. In addition, MCLR induced cellular structural damage and resulted in the production of intracellular reactive oxygen species (ROS) and lipid peroxidation. Moreover, protein phosphatase (PP) activity was inhibited and some serum biochemistry parameters were altered. These results suggest an early molecular mechanism behind the hepatotoxicity induced by maternal MC exposure and highlight the importance of monitoring MC concentrations in new-born mammals. (C) 2016 Elsevier Ltd. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Environmental Sciences |
| 研究领域[WOS] | Environmental Sciences & Ecology |
| 关键词[WOS] | INDUCED DNA-DAMAGE ; IN-VIVO ; ALDEHYDE DEHYDROGENASE ; CELLS ; CYANOBACTERIA ; GLUTATHIONE ; METABOLISM ; TOXICITY ; HEALTH ; TOXIN |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000376800000024 |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/27980]  |
| 专题 | 水生生物研究所_水环境工程研究中心 |
| 作者单位 | Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Donghu South Rd 7, Wuhan 430072, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Sujuan,Xie, Ping,Chen, Jun,et al. A proteomic study on liver impairment in rat pups induced by maternal microcystin-LR exposure[J]. ENVIRONMENTAL POLLUTION,2016,212:197-207. |
| APA | Zhao, Sujuan,Xie, Ping,Chen, Jun,Liu, Luyi,&Fan, Huihui.(2016).A proteomic study on liver impairment in rat pups induced by maternal microcystin-LR exposure.ENVIRONMENTAL POLLUTION,212,197-207. |
| MLA | Zhao, Sujuan,et al."A proteomic study on liver impairment in rat pups induced by maternal microcystin-LR exposure".ENVIRONMENTAL POLLUTION 212(2016):197-207. |
入库方式： OAI收割
来源：水生生物研究所
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