Endocrine Disruption throughout the Hypothalamus-Pituitary-Gonadal-Liver (HPGL) Axis in Marine Medaka (Oryzias melastigma) Chronically Exposed to the Antifouling and Chemopreventive Agent, 3,3 '-Diindolylmethane (DIM)
文献类型：期刊论文
| 作者 | Chen, Lianguo1,2; Ye, Rui3; Zhang, Weipeng1,2; Hu, Chenyan4; Zhou, Bingsheng5; Peterson, Drew R.3; Au, Doris W. T.3; Lam, Paul K. S.3; Qian, Pei-Yuan1,2 |
| 刊名 | CHEMICAL RESEARCH IN TOXICOLOGY
 |
| 出版日期 | 2016-06-01 |
| 卷号 | 29期号:6页码:1020-1028 |
| ISSN号 | 0893-228X |
| 英文摘要 | Despite being proposed as a promising antifouling and chemopreventive agent, the environmental risks of 3,3 '-diindolylrnethane (DIM) are scarcely investigated. Therefore, this study used adult marine medaka (Oryzias melastigma) as a model organism to examine the toxicological effects and underlying mechanism of DIM throughout the hypothalamus pituitary gonadal liver (HPGL) axis following 28 days of exposure to low DIM concentrations (0 and 8.46 mu g/L). The results showed that altered gene transcription in the hypothalamus, pituitary, and gonads contributed to the great imbalance in hormone homeostasis. The lowered estradiol (E-2)/testosterone (T) and E-2/11-keto-testosterone (11-KT) ratios in female plasma resulted in decreased synthesis and levels of vitellogenin (VTG) and choriogenin in the liver and plasma, and vice versa in males. Subsequently, VTG and choriogenin deficiency blocked the reproductive function of the ovary as indicated by decreased fecundity and offspring viability, whereas in male medaka, DIM mainly targeted the liver and induced severe vacuolization. Proteomic profiling of plasma revealed that the sex-specific susceptibility to DIM could be attributed to the increased detoxification and oxidative defense in males. Overall, this study identified the endocrine disruption and reproductive impairment potency of DIM and first elucidated its mechanisms of action in medaka. The differential responses to DIM (estrogenic activities in the male but antiestrogenic activities in the female) provided sensitive biomarkers characteristic of each sex. Considering the chemical stability and potent endocrine disturbance at low concentration, the application of DIM either as an antifouling or chemopreventive agent should be approached with caution in marine environments. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences |
| 类目[WOS] | Chemistry, Medicinal ; Chemistry, Multidisciplinary ; Toxicology |
| 研究领域[WOS] | Pharmacology & Pharmacy ; Chemistry ; Toxicology |
| 关键词[WOS] | GENE-EXPRESSION ANALYSIS ; PAINT BOOSTER BIOCIDES ; RAINBOW-TROUT ; 4,5-DICHLORO-2-N-OCTYL-4-ISOTHIAZOLIN-3-ONE DCOIT ; COMPOUND BUTENOLIDE ; FATHEAD MINNOW ; ZEBRAFISH ; TUMOR ; INDOLE-3-CARBINOL ; RESPONSES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000378369700010 |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/28008]  |
| 专题 | 水生生物研究所_水环境工程研究中心 |
| 作者单位 | 1.Hong Kong Univ Sci & Technol, HKUST Shenzhen Res Inst, Hong Kong, Hong Kong, Peoples R China 2.Hong Kong Univ Sci & Technol, Div Life Sci, Hong Kong, Hong Kong, Peoples R China 3.City Univ Hong Kong, Dept Biol & Chem, State Key Lab Marine Pollut, Kowloon, Hong Kong, Peoples R China 4.City Univ Hong Kong, Sch Energy & Environm, Kowloon, Hong Kong, Peoples R China 5.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Lianguo,Ye, Rui,Zhang, Weipeng,et al. Endocrine Disruption throughout the Hypothalamus-Pituitary-Gonadal-Liver (HPGL) Axis in Marine Medaka (Oryzias melastigma) Chronically Exposed to the Antifouling and Chemopreventive Agent, 3,3 '-Diindolylmethane (DIM)[J]. CHEMICAL RESEARCH IN TOXICOLOGY,2016,29(6):1020-1028. |
| APA | Chen, Lianguo.,Ye, Rui.,Zhang, Weipeng.,Hu, Chenyan.,Zhou, Bingsheng.,...&Qian, Pei-Yuan.(2016).Endocrine Disruption throughout the Hypothalamus-Pituitary-Gonadal-Liver (HPGL) Axis in Marine Medaka (Oryzias melastigma) Chronically Exposed to the Antifouling and Chemopreventive Agent, 3,3 '-Diindolylmethane (DIM).CHEMICAL RESEARCH IN TOXICOLOGY,29(6),1020-1028. |
| MLA | Chen, Lianguo,et al."Endocrine Disruption throughout the Hypothalamus-Pituitary-Gonadal-Liver (HPGL) Axis in Marine Medaka (Oryzias melastigma) Chronically Exposed to the Antifouling and Chemopreventive Agent, 3,3 '-Diindolylmethane (DIM)".CHEMICAL RESEARCH IN TOXICOLOGY 29.6(2016):1020-1028. |
入库方式： OAI收割
来源：水生生物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。