MRI-guided liposomes for targeted tandem chemotherapy and therapeutic response prediction
文献类型：期刊论文
| 作者 | Ren, Lili; Chen, Shizhen; Li, Haidong; Zhang, Zhiying; Zhong, Jianping; Liu, Maili; Zhou, Xin |
| 刊名 | ACTA BIOMATERIALIA
 |
| 出版日期 | 2016-04-15 |
| 卷号 | 35页码:260-268 |
| 关键词 | Non-small-cell lung cancer Magnetic resonance imaging Paclitaxel Carboplatin Liposome |
| 英文摘要 | Liposomes are effective drug delivery systems that can be functionalized with imaging contrast agents, providing both diagnosis and monitoring of disease treatment. Here we describe the design of a theranostic liposomal drug delivery system whose biodistribution can be real time imaged by contrast enhanced MRI and can achieve tandem chemotherapy drug delivery. Because T-1 relaxation of MRI depends upon the chemical structure of contrast agent as well as its interaction with neighbor environment, we rationally designed a functional liposome for in vivo T-1 enhanced MRI. The liposome shows a 36-fold higher T-1 relaxation rate over the commercial MRI contrast agent Omniscan (R) and a long circulation time up to 300 min in vivo. Moreover, the multifunctional liposome carries both hydrophobic and hydrophilic chemotherapeutic drugs, can synergistically enhance therapeutic effects of multiple drugs and selectively deliver them to lung tumors, leading to lower doses, toxicity and sustained release. The nanoparticles, which exhibit favorable biodistributions to tumors, offer new possibilities for the simultaneous delivery of more than one drug and the evaluation of therapeutic response in vivo by T-1 enhanced MRI. |
| WOS标题词 | Science & Technology ; Technology |
| 类目[WOS] | Engineering, Biomedical ; Materials Science, Biomaterials |
| 研究领域[WOS] | Engineering ; Materials Science |
| 关键词[WOS] | CELL LUNG-CANCER ; RANDOMIZED PHASE-III ; PLATINUM ANTICANCER DRUGS ; IN-VIVO ; ANTITUMOR-ACTIVITY ; PACLITAXEL-CARBOPLATIN ; ONCOLOGY-GROUP ; TUMOR-CELLS ; CISPLATIN ; DELIVERY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000375162200024 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/9332]  |
| 专题 | 武汉物理与数学研究所_磁共振基础研究部 |
| 作者单位 | Chinese Acad Sci, Key Lab Magnet Resonance Biol Syst, State Key Lab Magnet Resonance & Atom & Mol Phys, Natl Ctr Magnet Resonance Wuhan,Wuhan Inst Phys &, Wuhan 430071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ren, Lili,Chen, Shizhen,Li, Haidong,et al. MRI-guided liposomes for targeted tandem chemotherapy and therapeutic response prediction[J]. ACTA BIOMATERIALIA,2016,35:260-268. |
| APA | Ren, Lili.,Chen, Shizhen.,Li, Haidong.,Zhang, Zhiying.,Zhong, Jianping.,...&Zhou, Xin.(2016).MRI-guided liposomes for targeted tandem chemotherapy and therapeutic response prediction.ACTA BIOMATERIALIA,35,260-268. |
| MLA | Ren, Lili,et al."MRI-guided liposomes for targeted tandem chemotherapy and therapeutic response prediction".ACTA BIOMATERIALIA 35(2016):260-268. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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