Im10A, a short conopeptide isolated from Conus imperialis and possesses two highly concentrated disulfide bridges and analgesic activity
文献类型：期刊论文
| 作者 | Yu, Shuo1; Du, Tianpeng2; Liu, Zhuguo1; Wu, Qiaoling1; Feng, Guixue1; Dong, Mingxin1; Zhou, Xiaowei1; Jiang, Ling2; Dai, Qiuyun1 |
| 刊名 | PEPTIDES
 |
| 出版日期 | 2016-07-01 |
| 卷号 | 81页码:15-20 |
| 关键词 | Conopeptide Im10A Isolation Synthesis NMR structure Analgesic activity |
| 英文摘要 | In the present study, we isolated, synthesized and NMR structurally characterized a novel conopeptide Im10A consisting of 11 amino acids (NTICCEGCMCY-NH2) from Conus imperialis. Unlike other conopeptides with four cysteine residues, Im10A had only two residues in loop 1 and one residue in loop 2 (CC-loop1-C-loop2-C), which formed a stable disulfide connectivity "I-IV, (framework X) with a type I beta-turn. Interestingly, Im10A exhibited 50.7% analgesic activity on rat partial sciatic nerve ligation (PNL) at 2 h after Im10A administration. However, 10 mu M Im10A exhibited no apparent effect on neuronal nicotinic acetylcholine receptor, and it did not target DRG voltage-dependent sodium, potassium and calcium ion channels and opioid receptor. To our knowledge, Im10A had the most concentrated disulfide bridges among conopeptides with four cysteine residues. This finding provided a new motif for the future development of biomimetic compounds. (C) 2016 Elsevier Inc. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy |
| 关键词[WOS] | CONOTOXIN DIVERSITY ; ALPHA-CONOTOXINS ; MOLECULAR-BASIS ; NACHR SUBTYPES ; VENOM ; MARMOREUS ; PEPTIDE ; SUPERFAMILY ; DISCOVERY ; CHANNEL |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000377301500003 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/9369]  |
| 专题 | 武汉物理与数学研究所_磁共振基础研究部 |
| 作者单位 | 1.Beijing Inst Biotechnol, Beijing 10071, Peoples R China 2.Chinese Acad Sci, Key Lab Magnet Resonance Biol Syst, Natl Ctr Magnet Resonance Wuhan,Wuhan Inst Phys &, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu, Shuo,Du, Tianpeng,Liu, Zhuguo,et al. Im10A, a short conopeptide isolated from Conus imperialis and possesses two highly concentrated disulfide bridges and analgesic activity[J]. PEPTIDES,2016,81:15-20. |
| APA | Yu, Shuo.,Du, Tianpeng.,Liu, Zhuguo.,Wu, Qiaoling.,Feng, Guixue.,...&Dai, Qiuyun.(2016).Im10A, a short conopeptide isolated from Conus imperialis and possesses two highly concentrated disulfide bridges and analgesic activity.PEPTIDES,81,15-20. |
| MLA | Yu, Shuo,et al."Im10A, a short conopeptide isolated from Conus imperialis and possesses two highly concentrated disulfide bridges and analgesic activity".PEPTIDES 81(2016):15-20. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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