Tumor growth affects the metabonomic phenotypes of multiple mouse non-involved organs in an A549 lung cancer xenograft model
文献类型：期刊论文
| 作者 | Xu, Shan1,2; Tian, Yuan2; Hu, Yili2; Zhang, Nijia1; Hu, Sheng3; Song, Dandan1; Wu, Zhengshun1; Wang, Yulan2,4; Cui, Yanfang1; Tang, Huiru5 |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2016-06-22 |
| 卷号 | 6 |
| 英文摘要 | The effects of tumorigenesis and tumor growth on the non-involved organs remain poorly understood although many research efforts have already been made for understanding the metabolic phenotypes of various tumors. To better the situation, we systematically analyzed the metabolic phenotypes of multiple non-involved mouse organ tissues (heart, liver, spleen, lung and kidney) in an A549 lung cancer xenograft model at two different tumor-growth stages using the NMR-based metabonomics approaches. We found that tumor growth caused significant metabonomic changes in multiple non-involved organ tissues involving numerous metabolic pathways, including glycolysis, TCA cycle and metabolisms of amino acids, fatty acids, choline and nucleic acids. Amongst these, the common effects are enhanced glycolysis and nucleoside/nucleotide metabolisms. These findings provided essential biochemistry information about the effects of tumor growth on the non-involved organs. |
| WOS标题词 | Science & Technology |
| 类目[WOS] | Multidisciplinary Sciences |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 关键词[WOS] | HIGH-FAT-DIET ; METABOLIC ALTERATIONS ; COLORECTAL-CANCER ; CHOLINE ; STATE ; MICE ; BIOSYNTHESIS ; SPECTROSCOPY ; PROGRESSION ; STATISTICS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000378219600001 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/9407]  |
| 专题 | 武汉物理与数学研究所_磁共振应用研究部 |
| 作者单位 | 1.Cent China Normal Univ, Coll Chem, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China 2.Univ Chinese Acad Sci, CAS Key Lab Magnet Resonance Biol Syst, State Key Lab Magnet Resonance & Atom & Mol Phys, Natl Ctr Magnet Resonance Wuhan,Wuhan Inst Phys &, Wuhan 430071, Peoples R China 3.Hubei Prov Canc Hosp, Dept Med Oncol, Wuhan 430079, Peoples R China 4.Zhejiang Univ, Collaborat Innovat Ctr Diag & Treatment Infect Di, Hangzhou 310058, Zhejiang, Peoples R China 5.Fudan Univ, Collaborat Innovat Ctr Genet & Dev, Key Lab Contemporary Anthropol,Metabon & Syst Bio, State Key Lab Genet Engn,Minist Educ,Sch Life Sci, Shanghai 200438, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Shan,Tian, Yuan,Hu, Yili,et al. Tumor growth affects the metabonomic phenotypes of multiple mouse non-involved organs in an A549 lung cancer xenograft model[J]. SCIENTIFIC REPORTS,2016,6. |
| APA | Xu, Shan.,Tian, Yuan.,Hu, Yili.,Zhang, Nijia.,Hu, Sheng.,...&Tang, Huiru.(2016).Tumor growth affects the metabonomic phenotypes of multiple mouse non-involved organs in an A549 lung cancer xenograft model.SCIENTIFIC REPORTS,6. |
| MLA | Xu, Shan,et al."Tumor growth affects the metabonomic phenotypes of multiple mouse non-involved organs in an A549 lung cancer xenograft model".SCIENTIFIC REPORTS 6(2016). |
入库方式： OAI收割
来源：武汉物理与数学研究所
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