Metabolomics Insights into the Modulatory Effects of Long-Term Low Calorie Intake in Mice
文献类型：期刊论文
| 作者 | Wu, Junfang1; Yang, Liu2; Li, Shoufeng2; Huang, Ping2; Liu, Yong2; Wang, Yulan1,3; Tang, Huiru1,4 |
| 刊名 | JOURNAL OF PROTEOME RESEARCH
 |
| 出版日期 | 2016-07-01 |
| 卷号 | 15期号:7页码:2299-2308 |
| 关键词 | calorie restriction high fat diet NMI metabonomics long-term diet interventions |
| 英文摘要 | There is increasing evidence that calorie restriction without malnutrition can extend longevity and delay the onset of age-associated disorders. Identifying the biochemical perturbations associated with different dietary habits would provide valuable insights into associations between metabolism and longevity. To reveal the effects of long-term dietary interventions on metabolic perturbations, we investigated serum and urinary metabolic changes induced by interactive high/low fat diet in combination with/without reduced caloric intake over a life span in mice using NMR-based metabonomics. We found that the high calorie dietary regime disturbed lipid metabolism, suppressed glycolysis and TCA cycles, stimulated oxidative stress, promoted nucleotide metabolism and gluconeogenesis, and perturbed gut microbiota host interactions. Such changes could be modified by long-term low calorie intake. Most importantly, we found that the calorie intake index exerts a dominant effect on metabolic perturbations irrespective of dietary regime. Our investigation provides a holistic view of the metabolic impact of long-term dietary interventions, which are important for detecting physiological changes and dietary effects on mammalian metabolism. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Biochemical Research Methods |
| 研究领域[WOS] | Biochemistry & Molecular Biology |
| 关键词[WOS] | HIGH-FAT-DIET ; INSULIN-RESISTANT MICE ; INDUCED OBESITY ; ENERGY RESTRICTION ; GUT MICROBIOTA ; BLOOD-PLASMA ; LIVER ; RAT ; NMR ; DISEASE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000379456400019 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/9457]  |
| 专题 | 武汉物理与数学研究所_磁共振应用研究部 |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan Ctr Magnet Resonance, Key Lab Magnet Resonance Biol Syst,State Key Lab, Wuhan 430071, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Nutr & Metab, Shanghai 200031, Peoples R China 3.Zhejiang Univ, Collaborat Innovat Ctr Diag & Treatment Infect Di, Hangzhou 310058, Zhejiang, Peoples R China 4.Fudan Univ, Sch Life Sci, State Key Lab Genet Engn, Collaborat Innovat Ctr Genet & Dev,Metabol & Syst, Shanghai 200433, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Junfang,Yang, Liu,Li, Shoufeng,et al. Metabolomics Insights into the Modulatory Effects of Long-Term Low Calorie Intake in Mice[J]. JOURNAL OF PROTEOME RESEARCH,2016,15(7):2299-2308. |
| APA | Wu, Junfang.,Yang, Liu.,Li, Shoufeng.,Huang, Ping.,Liu, Yong.,...&Tang, Huiru.(2016).Metabolomics Insights into the Modulatory Effects of Long-Term Low Calorie Intake in Mice.JOURNAL OF PROTEOME RESEARCH,15(7),2299-2308. |
| MLA | Wu, Junfang,et al."Metabolomics Insights into the Modulatory Effects of Long-Term Low Calorie Intake in Mice".JOURNAL OF PROTEOME RESEARCH 15.7(2016):2299-2308. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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