Alternol inhibits the proliferation and induces the differentiation of the mouse melanoma B16F0 cell line
文献类型：期刊论文
| 作者 | Wang, CX; Xu, WJ; Hao, WJ; Wang, BS; Zheng, QS |
| 刊名 | ONCOLOGY REPORTS
 |
| 出版日期 | 2016-08-01 |
| 卷号 | 36期号:2页码:1150-1156 |
| 关键词 | alternol melanoma cell proliferation differentiation tyrosinase melanin |
| ISSN号 | 1021-335X |
| 产权排序 | [Wang, Caixia; Xu, Wenjuan; Hao, Wenjin; Wang, Bingsheng; Zheng, Qiusheng] Binzhou Med Univ, Yantai 264003, Shandong, Peoples R China; [Wang, Caixia] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Shandong, Peoples R China; [Wang, Caixia] Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 通讯作者 | Wang, BS ; Zheng, QS (reprint author), Binzhou Med Univ, Yantai 264003, Shandong, Peoples R China. wang617424@163.com ; zqsyt@sohu.com |
| 英文摘要 | High malignant potential and low susceptibility to treatment are characteristics of malignant melanoma. Alternol, a novel compound purified from microbial fermentation products obtained from the bark of the yew tree, exhibits a variety of antitumor activities. Based on these findings, the aim of the present study was to extend the knowledge on the antineoplastic effect of alternol in the mouse melanoma B16F0 cell line. Alternol significantly inhibited the proliferation and colony formation of B16F0 cells in a dose-dependent manner as detected by MTT and soft agar colony formation assays. NaOH alkaline lysis and oxidation of Dopa indicated that alternol enhanced the melanin content and tyrosinase activity of the B16F0 cells and results also showed a dose-response relationship. Morphologic changes accompanied by extended dendrites were discovered in the B16F0 cells after treatment with alternol. Furthermore, the mRNA levels of tyrosinase, Trpl and Trp2 were increased by alternol. Our results confirmed that alternol possesses marked antineoplastic properties against melanoma cells, indicating that this microbial fermentation product is a promising agent for the differentiation therapy of cancer. The inhibition of cell proliferation and colony formation by alternol was associated with both cytotoxicity and induction of differentiation. |
| 研究领域[WOS] | Oncology |
| 关键词[WOS] | SKIN PIGMENTATION ; COMPOUND ALTERNOL ; RETINOIC ACID ; CANCER-CELLS ; APOPTOSIS ; MELANOCYTES ; GROWTH ; ACTIVATION ; EXPRESSION ; LEUKEMIA |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000379248700067 |
| 源URL | [http://ir.yic.ac.cn/handle/133337/17103]  |
| 专题 | 烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室 |
| 作者单位 | 1.Binzhou Med Univ 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat 3.Univ Chinese Acad Sci |
| 推荐引用方式 GB/T 7714 | Wang, CX,Xu, WJ,Hao, WJ,et al. Alternol inhibits the proliferation and induces the differentiation of the mouse melanoma B16F0 cell line[J]. ONCOLOGY REPORTS,2016,36(2):1150-1156. |
| APA | Wang, CX,Xu, WJ,Hao, WJ,Wang, BS,&Zheng, QS.(2016).Alternol inhibits the proliferation and induces the differentiation of the mouse melanoma B16F0 cell line.ONCOLOGY REPORTS,36(2),1150-1156. |
| MLA | Wang, CX,et al."Alternol inhibits the proliferation and induces the differentiation of the mouse melanoma B16F0 cell line".ONCOLOGY REPORTS 36.2(2016):1150-1156. |
入库方式： OAI收割
来源：烟台海岸带研究所
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