Proteomic and metabolomic analysis on the toxicological effects of As (III) and As (V) in juvenile mussel Mytilus galloprovincialis
文献类型：期刊论文
| 作者 | Yu, DL; Ji, CL ; Zhao, JM; Wu, HF
|
| 刊名 | CHEMOSPHERE
 |
| 出版日期 | 2016-05-01 |
| 卷号 | 150页码:194-201 |
| 关键词 | Mytilus galloprovincialis Arsenic Toxicological effects Metabolomics Proteomics |
| ISSN号 | 0045-6535 |
| 产权排序 | [Yu, Deliang; Ji, Chenglong; Zhao, Jianmin; Wu, Huifeng] Chinese Acad Sci, Key Lab Coastal Zone Environm Proc, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai Inst Coastal Zone Res YIC,YICCAS, Yantai 264003, Peoples R China; [Yu, Deliang] Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 通讯作者 | Wu, HF (reprint author), Chinese Acad Sci, Key Lab Coastal Zone Environm Proc, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai Inst Coastal Zone Res YIC,YICCAS, Yantai 264003, Peoples R China. hfwu@yic.ac.cn |
| 英文摘要 | Inorganic arsenic (As) is a known pollutant including two chemical forms (arsenite (As III) and arsenate (As V)), in marine and coastal environment. Marine mussel Mytilus galloprovincialis is an important environmental monitoring species around the world. In this study, we focused on valence-specific responses of As in juvenile mussel M. galloprovincialis using a combined proteomic and metabolomic approach. Metabolic responses indicated that As (III) mainly caused disturbance in osmotic regulation in juvenile mussels. As (V) caused disturbances in both osmotic regulation and energy metabolism marked by different metabolic responses, including betaine, taurine, glucose and glycogen. Proteomic responses exhibited that As (III) had a significant negative effect on cytoskeleton and cell structure (actin and collagen alpha-6(VI) chain). As (V) affected some key enzymes involved in energy metabolism (cytosolic malate dehydrogenase, cMDH) and cell development (ornithine aminotransferase and astacin). Overall, all these results confirmed the valence-specific responses in juvenile mussels to As exposures. These findings demonstrate that a combined metabolomic and proteomic approach could provide an important insight into the toxicological effects of environmental pollutants in organisms. (C) 2016 Elsevier Ltd. All rights reserved. |
| 研究领域[WOS] | Environmental Sciences & Ecology |
| 关键词[WOS] | OYSTER CRASSOSTREA-GIGAS ; MALATE-DEHYDROGENASES ; ELEVATED PCO(2) ; TRACE-METALS ; EXPOSURE ; NMR ; TOXICITY ; PROTEINS ; STRESS ; HEALTH |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000372765100025 |
| 源URL | [http://ir.yic.ac.cn/handle/133337/17027]  |
| 专题 | 烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室 烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Coastal Zone Environm Proc, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai Inst Coastal Zone Res YIC,YICCAS 2.Univ Chinese Acad Sci |
| 推荐引用方式 GB/T 7714 | Yu, DL,Ji, CL,Zhao, JM,et al. Proteomic and metabolomic analysis on the toxicological effects of As (III) and As (V) in juvenile mussel Mytilus galloprovincialis[J]. CHEMOSPHERE,2016,150:194-201. |
| APA | Yu, DL,Ji, CL,Zhao, JM,&Wu, HF.(2016).Proteomic and metabolomic analysis on the toxicological effects of As (III) and As (V) in juvenile mussel Mytilus galloprovincialis.CHEMOSPHERE,150,194-201. |
| MLA | Yu, DL,et al."Proteomic and metabolomic analysis on the toxicological effects of As (III) and As (V) in juvenile mussel Mytilus galloprovincialis".CHEMOSPHERE 150(2016):194-201. |
入库方式： OAI收割
来源：烟台海岸带研究所
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