Opposite monosynaptic scaling of BLP-vCA1 inputs governs hopefulness- and helplessness-modulated spatial learning and memory
文献类型：期刊论文
| 作者 | Yang, Ying1,2; Wang, Zhi-Hao1,2; Jin, Sen5; Gao, Di1,2; Liu, Nan3,4; Chen, Shan-Ping3,4; Zhang, Sinan5; Liu, Qing5; Liu, Enjie1,2; Wang, Xin1,2 |
| 刊名 | Nature Communications
 |
| 出版日期 | 2016-07-01 |
| 卷号 | 7 |
| 英文摘要 | Different emotional states lead to distinct behavioural consequences even when faced with the same challenging events. Emotions affect learning and memory capacities, but the underlying neurobiological mechanisms remain elusive. Here we establish models of learned helplessness (LHL) and learned hopefulness (LHF) by exposing animals to inescapable foot shocks or with anticipated avoidance trainings. The LHF animals show spatial memory potentiation with excitatory monosynaptic upscaling between posterior basolateral amygdale (BLP) and ventral hippocampal CA1 (vCA1), whereas the LHL show memory deficits with an attenuated BLP-vCA1 connection. Optogenetic disruption of BLP-vCA1 inputs abolishes the effects of LHF and impairs synaptic plasticity. By contrast, targeted BLP-vCA1 stimulation rescues the LHL-induced memory deficits and mimics the effects of LHF. BLP-vCA1 stimulation increases synaptic transmission and dendritic plasticity with the upregulation of CREB and intrasynaptic AMPA receptors in CA1. These findings indicate that opposite excitatory monosynaptic scaling of BLP-vCA1 controls LHF- and LHL-modulated spatial memory, revealing circuit-specific mechanisms linking emotions to memory. |
| WOS标题词 | Science & Technology |
| 类目[WOS] | Multidisciplinary Sciences |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 关键词[WOS] | LONG-TERM POTENTIATION ; ALZHEIMERS-DISEASE ; HIPPOCAMPAL-FORMATION ; DEPRESSIVE SYMPTOMS ; DORSAL HIPPOCAMPUS ; IN-VIVO ; AMYGDALA ; STRESS ; FEAR ; PROJECTIONS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000380746900001 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/9478]  |
| 专题 | 武汉物理与数学研究所_磁共振应用研究部 |
| 作者单位 | 1.Huazhong Univ Sci & Technol, Dept Pathophysiol, Sch Basic Med, Wuhan 430030, Peoples R China 2.Huazhong Univ Sci & Technol, Tongji Med Coll, Collaborat Innovat Ctr Brain Sci, Key Lab,Minist Educ China Neurol Disorders, Wuhan 430030, Peoples R China 3.Chinese Acad Sci, Shenzhen Key Lab Neuropsychiat Modulat, Shenzhen 518055, Peoples R China 4.Chinese Acad Sci, Collaborat Innovat Ctr Brain Sci, CAS Ctr Excellence Brain Sci, Shenzhen Inst Adv Technol, Shenzhen 518055, Peoples R China 5.Chinese Acad Sci, Wuhan Inst Phys & Math, CAS Ctr Excellence Brain Sci, Wuhan 430071, Peoples R China 6.Huazhong Univ Sci & Technol, Sch Life Sci & Technol, Wuhan 430074, Peoples R China 7.Coinnovat Ctr Neuroregenerat, Nantong 226000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Ying,Wang, Zhi-Hao,Jin, Sen,et al. Opposite monosynaptic scaling of BLP-vCA1 inputs governs hopefulness- and helplessness-modulated spatial learning and memory[J]. Nature Communications,2016,7. |
| APA | Yang, Ying.,Wang, Zhi-Hao.,Jin, Sen.,Gao, Di.,Liu, Nan.,...&Wang, Jian-Zhi.(2016).Opposite monosynaptic scaling of BLP-vCA1 inputs governs hopefulness- and helplessness-modulated spatial learning and memory.Nature Communications,7. |
| MLA | Yang, Ying,et al."Opposite monosynaptic scaling of BLP-vCA1 inputs governs hopefulness- and helplessness-modulated spatial learning and memory".Nature Communications 7(2016). |
入库方式： OAI收割
来源：武汉物理与数学研究所
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