Pathophysiologic mechanisms of biomedical nanomaterials
文献类型：期刊论文
| ; | |
| 作者 | Wang LM(王黎明) ; Chen CY(陈春英); Wang, LM; Chen, CY
|
| 刊名 | TOXICOLOGY AND APPLIED PHARMACOLOGY
 ; TOXICOLOGY AND APPLIED PHARMACOLOGY
|
| 出版日期 | 2016 ; 2016 |
| 卷号 | 299页码:30-40 |
| 关键词 | Nanomaterials Pathophysiologic effects Nano-bio interaction Safety Biomedical effects |
| ISSN号 | 0041-008X |
| DOI | 10.1016/j.taap.2016.01.022 |
| 文献子类 | Article |
| 英文摘要 | Nanomaterials (NMs) have been widespread used in biomedical fields, daily consuming, and even food industry. It is crucial to understand the safety and biomedical efficacy of NMs. In this review, we summarized the recent progress about the physiological and pathological effects of NMs from several levels: protein-nano interface, NM-subcellular structures, and cell-cell interaction. We focused on the detailed information of nano-bio interaction, especially about protein adsorption, intracellular trafficking, biological barriers, and signaling pathways as well as the associated mechanism mediated by nanomaterials. We also introduced related analytical methods that are meaningful and helpful for biomedical effect studies in the future. We believe that knowledge about pathophysiologic effects of NMs is not only significant for rational design of medical NMs but also helps predict their safety and further improve their applications in the future. (C) 2016 Elsevier Inc All rights reserved. |
| 电子版国际标准刊号 | 1096-0333 |
| 语种 | 英语 ; 英语 |
| WOS记录号 | WOS:000374435900005 ; WOS:000374435900005 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/248018]  |
| 专题 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Wang LM,Chen CY,Wang, LM,et al. Pathophysiologic mechanisms of biomedical nanomaterials, Pathophysiologic mechanisms of biomedical nanomaterials[J]. TOXICOLOGY AND APPLIED PHARMACOLOGY, TOXICOLOGY AND APPLIED PHARMACOLOGY,2016, 2016,299, 299:30-40. |
| APA | 王黎明,陈春英,Wang, LM,&Chen, CY.(2016).Pathophysiologic mechanisms of biomedical nanomaterials.TOXICOLOGY AND APPLIED PHARMACOLOGY,299,30-40. |
| MLA | 王黎明,et al."Pathophysiologic mechanisms of biomedical nanomaterials".TOXICOLOGY AND APPLIED PHARMACOLOGY 299(2016):30-40. |
入库方式： OAI收割
来源：高能物理研究所
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