Characterization and Comparison of the Structural Features, Immune-Modulatory and Anti-Avian Influenza Virus Activities Conferred by Three Algal Sulfated Polysaccharides
文献类型：期刊论文
| 作者 | Song, Lin1,2 ; Chen, Xiaolin1; Liu, Xiaodong3; Zhang, Fubo3; Hu, Linfeng1; Yue, Yang1,2; Li, Kecheng1; Li, Pengcheng1
|
| 刊名 | MARINE DRUGS
 |
| 出版日期 | 2016 |
| 卷号 | 14期号:1 |
| 关键词 | marine macroalgae sulfated polysaccharides structure features immune enhancement anti-AIV |
| 英文摘要 | Three marine macroalgae, i.e., Grateloupia filicina, Ulva pertusa and Sargassum qingdaoense, were selected as the deputies of Rhodophyta, Chlorophyta and Ochrophyta for comparative analysis of the molecular structures and biological activities of sulfated polysaccharides (SP). The ratio of water-soluble polysaccharides, the monosaccharide composition and the sulfated contents of three extracted SPs were determined, and their structures were characterized by Fourier transformation infrared spectroscopy. In addition, biological activity analysis showed that all three SPs had immune-modulatory activity both in vitro and in vivo, and SPs from S. qingdaoense had the best effect. Further bioassays showed that three SPs could not only enhance the immunity level stimulated by inactivated avian influenza virus (AIV) in vivo but also significantly inhibited the activity of activated AIV (H9N2 subtype) in vitro. G. filicina SP exhibited the strongest anti-AIV activity. These results revealed the variations in structural features and bioactivities among three SPs and indicated the potential adjuvants for immune-enhancement and anti-AIV. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000374586800004 |
| 版本 | 出版稿 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/131080]  |
| 专题 | 海洋研究所_海洋生物技术研发中心 海洋研究所_实验海洋生物学重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, 7 Nanhai Rd, Qingdao 266071, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Qingdao Agr Univ, Coll Anim Sci & Technol, 700 Changcheng Rd, Qingdao 266109, Peoples R China |
| 推荐引用方式 GB/T 7714 | Song, Lin,Chen, Xiaolin,Liu, Xiaodong,et al. Characterization and Comparison of the Structural Features, Immune-Modulatory and Anti-Avian Influenza Virus Activities Conferred by Three Algal Sulfated Polysaccharides[J]. MARINE DRUGS,2016,14(1). |
| APA | Song, Lin.,Chen, Xiaolin.,Liu, Xiaodong.,Zhang, Fubo.,Hu, Linfeng.,...&Li, Pengcheng.(2016).Characterization and Comparison of the Structural Features, Immune-Modulatory and Anti-Avian Influenza Virus Activities Conferred by Three Algal Sulfated Polysaccharides.MARINE DRUGS,14(1). |
| MLA | Song, Lin,et al."Characterization and Comparison of the Structural Features, Immune-Modulatory and Anti-Avian Influenza Virus Activities Conferred by Three Algal Sulfated Polysaccharides".MARINE DRUGS 14.1(2016). |
入库方式： OAI收割
来源：海洋研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。