Independent Evolution of Six Families of Halogenating Enzymes
文献类型：期刊论文
| 作者 | Xu, Gangming; Wang, Bin-Gui
|
| 刊名 | PLOS ONE
 |
| 出版日期 | 2016-05-06 |
| 卷号 | 11期号:5 |
| 英文摘要 | Halogenated natural products are widespread in the environment, and the halogen atoms are typically vital to their bioactivities. Thus far, six families of halogenating enzymes have been identified: cofactor-free haloperoxidases (HPO), vanadium-dependent haloperoxidases (V-HPO), heme iron-dependent haloperoxidases (HI-HPO), non-heme iron-dependent halogenases (NI-HG), flavin-dependent halogenases (F-HG), and S-adenosyl-L-methionine (SAM)-dependent halogenases (S-HG). However, these halogenating enzymes with similar biological functions but distinct structures might have evolved independently. Phylogenetic and structural analyses suggest that the HPO, V-HPO, HI-HPO, NI-HG, FHG, and S-HG enzyme families may have evolutionary relationships to the alpha/beta hydrolases, acid phosphatases, peroxidases, chemotaxis phosphatases, oxidoreductases, and SAM hydroxide adenosyltransferases, respectively. These halogenating enzymes have established sequence homology, structural conservation, and mechanistic features within each family. Understanding the distinct evolutionary history of these halogenating enzymes will provide further insights into the study of their catalytic mechanisms and halogenation specificity. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000375677000028 |
| 版本 | 出版稿 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/131067]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 作者单位 | Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Gangming,Wang, Bin-Gui. Independent Evolution of Six Families of Halogenating Enzymes[J]. PLOS ONE,2016,11(5). |
| APA | Xu, Gangming,&Wang, Bin-Gui.(2016).Independent Evolution of Six Families of Halogenating Enzymes.PLOS ONE,11(5). |
| MLA | Xu, Gangming,et al."Independent Evolution of Six Families of Halogenating Enzymes".PLOS ONE 11.5(2016). |
入库方式： OAI收割
来源：海洋研究所
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