精神分裂症患者脑静息态默认网络和中心执行网络及突显网络关系的初步探讨
文献类型：期刊论文
| 作者 | 黄欢1; 王惠玲1; 周媛1 ; 陈军1; 邹寄林1; 陈诚1; 吴士豪1; 李培福1; 蒋田仔1
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| 刊名 | 中华精神科杂志
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| 出版日期 | 2015 |
| 卷号 | 48期号:3页码:175-181 |
| 关键词 | 精神分裂症 磁共振成像 默认网络 中心执行网络 突显网络 功能连接 Schizophrenia Magnetic resonance imaging Default mode network Central-executive network Salience network Functional connectivity |
| 其他题名 | Aberrant functional connectivity within and across the default mode, central-executive, and salience network in patients with schizophrenia: a resting-state functional magnetic resonance imaging study |
| 中文摘要 | 目的 探讨精神分裂症患者脑静息态默认网络、中心执行网络及突显网络的网络内及网络间的功能连接特点.方法 对74例精神分裂症患者(患者组)和79名相匹配的健康者(对照组)进行静息态fMRI扫描.采取功能连接分析方法,以内侧前额叶皮质及右侧前岛叶为感兴趣区域分别提取默认网络、中心执行网络及突显网络,分析3个网络内及网络间静息态功能连接情况;并对有差异的功能连接与精神症状及病程等进行偏相关分析.结果 与对照组相比,患者组内侧前额叶皮质与双侧背外侧前额叶皮质(左侧-0.02±0.18与-0.12±0.12,t=4.25,P＜0.01;右侧-0.02±0.11与-0.10±0.10,t=5.40,P＜0.01)、双侧豆状壳核(左侧0.14±0.12与0.04±0.10,t=5.03,P＜0.01;右侧0.13±0.11与0.03±0.98,t=4.96,P＜0.01)的功能连接增强;右侧前岛叶与左侧额中回(-0.05±0.17与-0.07±0.17,t=4.60,P＜0.01)及楔前叶/后扣带回(0.01±0.13与-0.09±0.14,t=4.01,P＜0.01)的功能连接增强(均采用高斯随机场理论校正,体素水平P＜0.01,簇水平P＜0.05);默认网络与中心执行网络、突显网络间的负向功能连接减小甚至消失(Bonferroni校正P＜0.05).患者组PANSS阳性症状分与右侧前岛叶与楔前叶/后扣带回皮质间的功能连接呈正相关(r=0.232,P=0.025);患者组病程与右侧前岛叶与左侧额中回(r=0.288,P=0.007)、楔前叶/后扣带回(r=0.196,P=0.049)间的功能连接呈正相关.结论 精神分裂症患者存在静息态默认网络、中心执行网络及突显网络3个网络间的连接异常,可能与精神分裂症的病理机制有关. |
| 英文摘要 | Objective To explore the neural profile of functional connectivity of default mode network (DMN),central-executive network(CEN),and salience network (SN) in patients with schizophrenia during a resting-state functional magnetic resonance imaging(rs-fMRI).Methods The SPM8,DPARSFA,CONN softwares combined with data-driven region of interest (ROI) analysis were used to investigate functional connectivity (FC) of the DMN,CEN,and SN in 74 patients with schizophrenia (SZ) and 79 ageand gender-matched normal controls (NC).Medial prefrontal cortex (MPFC) was selected as seed region for identifying the DMN and CEN while right anterior insula (rAI) for the SN.Voxel-wise functional connectivity analyses were performed between MPFC and rAI while pair-wise functional connectivity analyses were conducted across DMN,CEN,and SN.Results Concerning the MPFC,SZ showed increased functional connectivity,comparing with NC,with bilateral dorsolateral prefrontal cortex (left:-0.02 ±0.18 vs.-0.12± 0.12,t=4.25,P＜0.01;right:-0.02±0.11 vs.-0.10±0.10,t=5.40,P＜0.01) and bilateral putamen (left:0.14± 0.12 vs.0.04±0.10,t=5.03,P＜0.01;right:0.13±0.11 vs.0.03±0.98,t=4.96,P＜0.01).With regard to rAI,increased functional connectivity between rAI and left middle frontal cortex (-0.05±0.17 vs.-0.07±0.17,t=4.60,P＜0.01) and between rAI and precuneus/posterior cingulate cortex (0.01±0.13 vs.-0.09±0.14,t=4.01,P＜0.01) were found in SZ comparison to NC (gaussian random field thaeory-corrected;voxel level P＜0.01,cluster level P＜0.05).Additionally,SZ also showed enhanced interconnectivity strengths of DMN-CEN and DMN-SN (Bonferroni-corrected,P＜0.05).Furthermore,partial correlation analyses showed that the increased functional connectivity between rAI and precuneus/posterior cingulate cortex was significantly correlated with PANSS-positve symptoms (r-0.232,P=0.025).Positive relationships were found between the duration of illness and functional connectivity between rAI and left middle frontal cortex (r=0.288,P=0.007) and between rAI and precuneus/posterior cingulate cortex (r=0.196,P=0.049).Conclusions This study provides evidence for resting state functional connectivity abnormalities of DMN,CEN,and SN in patients with schizophrenia.These aberrant functional connectivities between some key brain regions of three networks may be responsible for certain schizophrenic symptoms,which could contribute to exploring the pathophysiological mechanisms of schizophrenia. |
| 学科主题 | 变态心理学;认知神经科学 |
| 原文出处 | http://d.wanfangdata.com.cn/Periodical/zhjsk201503016 |
| 语种 | 中文 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/20237]  |
| 专题 | 心理研究所_社会与工程心理学研究室 |
| 作者单位 | 1.武汉大学人民医院精神科 2.中国科学院心理研究所 3.武汉大学人民医院放射科 4.中国科学院自动化研究所 |
| 推荐引用方式 GB/T 7714 | 黄欢,王惠玲,周媛,等. 精神分裂症患者脑静息态默认网络和中心执行网络及突显网络关系的初步探讨[J]. 中华精神科杂志,2015,48(3):175-181. |
| APA | 黄欢.,王惠玲.,周媛.,陈军.,邹寄林.,...&蒋田仔.(2015).精神分裂症患者脑静息态默认网络和中心执行网络及突显网络关系的初步探讨.中华精神科杂志,48(3),175-181. |
| MLA | 黄欢,et al."精神分裂症患者脑静息态默认网络和中心执行网络及突显网络关系的初步探讨".中华精神科杂志 48.3(2015):175-181. |
入库方式： OAI收割
来源：心理研究所
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