Cyc17, a meiosis-specific cyclin, is essential for anaphase initiation and chromosome segregation in Tetrahymena thermophila
文献类型：期刊论文
| 作者 | Yan, Guan-Xiong1,2; Dang, Huai3; Tian, Miao1,4,5; Zhang, Jing1,2; Shodhan, Anura4,5; Ning, Ying-Zhi3; Xiong, Jie1; Miao, Wei1 |
| 刊名 | CELL CYCLE
 |
| 出版日期 | 2016 |
| 卷号 | 15期号:14页码:1855-1864 |
| 关键词 | anaphase initiation cyclin chromosome segregation meiosis Tetrahymena thermophila |
| ISSN号 | 1538-4101 |
| 英文摘要 | Although the role of cyclins in controlling nuclear division is well established, their function in ciliate meiosis remains unknown. In ciliates, the cyclin family has undergone massive expansion which suggests that diverse cell cycle systems exist, and this warrants further investigation. A screen for cyclins in the model ciliate Tetrahymena thermophila showed that there are 34 cyclins in this organism. Only 1 cyclin, Cyc17, contains the complete cyclin core and is specifically expressed during meiosis. Deletion of CYC17 led to meiotic arrest at the diakinesis-like metaphase I stage. Expression of genes involved in DNA metabolism and chromosome organization (chromatin remodeling and basic chromosomal structure) was repressed in cyc17 knockout matings. Further investigation suggested that Cyc17 is involved in regulating spindle pole attachment, and is thus essential for chromosome segregation at meiosis. These findings suggest a simple model in which chromosome segregation is influenced by Cyc17. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Cell Biology |
| 研究领域[WOS] | Cell Biology |
| 关键词[WOS] | SPINDLE ASSEMBLY CHECKPOINT ; GENOME-WIDE ANALYSIS ; BUDDING YEAST ; SACCHAROMYCES-CEREVISIAE ; INTERACTIVE TREE ; GENE ONTOLOGY ; AURORA-B ; RNA-SEQ ; EXPRESSION ; PROTEIN |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000382232100013 |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/28375]  |
| 专题 | 水生生物研究所_淡水生态学研究中心_学位论文 |
| 作者单位 | 1.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Northwest Normal Univ, Coll Life Sci, Lanzhou, Peoples R China 4.Univ Vienna, Dept Chromosome Biol, Ctr Mol Biol, Vienna, Austria 5.Univ Vienna, Max F Perutz Labs, Ctr Mol Biol, Vienna, Austria |
| 推荐引用方式 GB/T 7714 | Yan, Guan-Xiong,Dang, Huai,Tian, Miao,et al. Cyc17, a meiosis-specific cyclin, is essential for anaphase initiation and chromosome segregation in Tetrahymena thermophila[J]. CELL CYCLE,2016,15(14):1855-1864. |
| APA | Yan, Guan-Xiong.,Dang, Huai.,Tian, Miao.,Zhang, Jing.,Shodhan, Anura.,...&Miao, Wei.(2016).Cyc17, a meiosis-specific cyclin, is essential for anaphase initiation and chromosome segregation in Tetrahymena thermophila.CELL CYCLE,15(14),1855-1864. |
| MLA | Yan, Guan-Xiong,et al."Cyc17, a meiosis-specific cyclin, is essential for anaphase initiation and chromosome segregation in Tetrahymena thermophila".CELL CYCLE 15.14(2016):1855-1864. |
入库方式： OAI收割
来源：水生生物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。