Disruption of dmc1 Produces Abnormal Sperm in Medaka (Oryzias latipes)
文献类型：期刊论文
| 作者 | Chen, Ji1; Cui, Xiaojuan1; Jia, Shaoting1,2; Luo, Daji3; Cao, Mengxi1; Zhang, Yunsheng1; Hu, Hongling1,2; Huang, Kaiyao1; Zhu, Zuoyan1; Hu, Wei1 |
| 刊名 | Scientific Reports
 |
| 出版日期 | 2016-08-02 |
| 卷号 | 6 |
| ISSN号 | 2045-2322 |
| 英文摘要 | DMC1 is a recombinase that is essential for meiotic synapsis. Experiments in extensive species of eukaryotes have indicated the independent role of DMC1 in repairing double strand breaks (DSBs) produced during meiosis I. Mutation of dmc1 in mice and human often leads to obstacles in spermatogenesis and male sterility. Here, we report on the disruption of dmc1 in male medaka (Oryzias latipes). Synapsis was disturbed in the mutant medaka testis nuclei, as observed in mice and other organisms. Unexpectedly, the mutant medaka could produce a few sperm and, although most of these had multiple tail or multiple head malformations, some of them could swim, and few of them even had insemination ability. Our transcriptome analysis showed that there was not a remarkable change in the expression of most of the genes involved in the pathways associated with the meiotic DNA repair and flagella assembly. Our results provided an indication of the accessory mechanisms that might be involved in the repair of DSBs during meiosis. In a species besides humans, we provided evidence that disorders in meiosis recombination might lead to the malformation of sperm. |
| WOS标题词 | Science & Technology |
| 类目[WOS] | Multidisciplinary Sciences |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 关键词[WOS] | DOUBLE-STRAND BREAKS ; MALE-INFERTILITY ; SYNAPTONEMAL COMPLEX ; HUMAN ANEUPLOIDY ; MEIOSIS ; GENE ; ZEBRAFISH ; FISH ; SPERMATOGENESIS ; RECOMBINATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000380639200002 |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/28389]  |
| 专题 | 水生生物研究所_鱼类生物学及渔业生物技术研究中心_学位论文 |
| 作者单位 | 1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, 7 Donghu South Rd, Wuhan 430072, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Wuhan Univ, Sch Basic Med Sci, Dept Genet, 185 Donghu East Rd, Wuhan 430071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Ji,Cui, Xiaojuan,Jia, Shaoting,et al. Disruption of dmc1 Produces Abnormal Sperm in Medaka (Oryzias latipes)[J]. Scientific Reports,2016,6. |
| APA | Chen, Ji.,Cui, Xiaojuan.,Jia, Shaoting.,Luo, Daji.,Cao, Mengxi.,...&Hu, Wei.(2016).Disruption of dmc1 Produces Abnormal Sperm in Medaka (Oryzias latipes).Scientific Reports,6. |
| MLA | Chen, Ji,et al."Disruption of dmc1 Produces Abnormal Sperm in Medaka (Oryzias latipes)".Scientific Reports 6(2016). |
入库方式： OAI收割
来源：水生生物研究所
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