GENDER DIFFERENCES OF PERIPHERAL PLASMA AND LIVER METABOLIC PROFILING IN APP/PS1 TRANSGENIC AD MICE
文献类型：期刊论文
| 作者 | Wu, Junfang1; Fu, Bin2; Lei, Hehua1; Tang, Huiru1,3; Wang, Yulan1,4 |
| 刊名 | NEUROSCIENCE
 |
| 出版日期 | 2016-09-22 |
| 卷号 | 332页码:160-169 |
| 关键词 | Alzheimer's disease gender difference metabonomics peripheral liver extracts fatty acids |
| 英文摘要 | Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive cognitive impairment. Currently, there is less knowledge of the involvement of the peripheral biofluid/organ in AD, compared with the central nervous system. In addition, with reported high morbidity in women in particular, it has become very important to explore whether gender difference in the peripheral metabolome is associated with AD. Here, we investigated metabolic responses of both plasma and liver tissues using an APP/PS1 double mutant transgenic mouse model with NMR spectroscopy, as well as analysis from serum biochemistry and histological staining. Fatty acid composition from plasma and liver extracts was analyzed using GC-FID/MS. We found clear gender differences in AD transgenic mice when compared with their wild-type counterparts. Female AD mice displayed more intensive responses, which were highlighted by higher levels of lipids, 3-hydroxybutyrate and nucleotide related metabolites, together with lower levels of glucose. These observations indicate that AD induces oxidative stress and impairs cellular energy metabolism in peripheral organs. Disturbances in AD male mice were milder with depletion of monounsaturated fatty acids. We also observed a higher activity of delta-6-desaturate and suppressed activity of delta-5-desaturate in female mice, whereas inhibited stearoyl-CoA-desaturase in male mice suggested that AD induced by the double mutant genes results in different fatty acids catabolism depending on gender. Our results provide metabolic clues into the peripheral biofluid/organs involved in AD, and we propose that a gender-specific scheme for AD treatment in men and women may be required. (C) 2016 IBRO. Published by Elsevier Ltd. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Neurosciences |
| 研究领域[WOS] | Neurosciences & Neurology |
| 关键词[WOS] | ESTIMATED DESATURASE ACTIVITIES ; FATTY-ACID-COMPOSITION ; AMYLOID PRECURSOR PROTEIN ; ALZHEIMERS-DISEASE ; SEX-DIFFERENCES ; COGNITIVE IMPAIRMENT ; PREFRONTAL CORTEX ; NMR-SPECTROSCOPY ; OXIDATIVE DAMAGE ; BIPOLAR DISORDER |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000381329800014 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/9504]  |
| 专题 | 武汉物理与数学研究所_磁共振应用研究部 |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Magnet Resonance & Atom & Mol Phys, CAS Key Lab Magnet Resonance Biol Syst, Wuhan Ctr Magnet Resonance,Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China 2.Hubei Prov Hosp Integrated Chinese & Western Med, Dept Neurol, Wuhan 430015, Peoples R China 3.Fudan Univ, Collaborat Innovat Ctr Genet & Dev, State Key Lab Genet Engn,Metabon & Syst Biol Lab, Minist Educ,Key Lab Contemporary Anthropol,Sch Li, Shanghai 200438, Peoples R China 4.Zhejiang Univ, Collaborat Innovat Ctr Diag & Treatment Infect Di, Hangzhou 310058, Zhejiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Junfang,Fu, Bin,Lei, Hehua,et al. GENDER DIFFERENCES OF PERIPHERAL PLASMA AND LIVER METABOLIC PROFILING IN APP/PS1 TRANSGENIC AD MICE[J]. NEUROSCIENCE,2016,332:160-169. |
| APA | Wu, Junfang,Fu, Bin,Lei, Hehua,Tang, Huiru,&Wang, Yulan.(2016).GENDER DIFFERENCES OF PERIPHERAL PLASMA AND LIVER METABOLIC PROFILING IN APP/PS1 TRANSGENIC AD MICE.NEUROSCIENCE,332,160-169. |
| MLA | Wu, Junfang,et al."GENDER DIFFERENCES OF PERIPHERAL PLASMA AND LIVER METABOLIC PROFILING IN APP/PS1 TRANSGENIC AD MICE".NEUROSCIENCE 332(2016):160-169. |
入库方式： OAI收割
来源：武汉物理与数学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。