围创伤期高唤醒对大鼠PTSD症状形成的预测作用
文献类型：学位论文
| 作者 | 王慧颖
|
| 学位类别 | 硕士 |
| 答辩日期 | 2011-05 |
| 授予单位 | 中国科学院研究生院 |
| 授予地点 | 北京 |
| 导师 | 李勇辉 |
| 关键词 | 创伤后应激障碍 高唤醒 吗啡 |
| 其他题名 | Peritraumatic Hyperarousal as a Predictor of PTSD Symptoms in Rats |
| 学位专业 | 心理学 |
| 中文摘要 | 创伤后应激障碍(Posttraumatic stress disorder, PTSD)已经成为危害人们健康的一大精神疾病，PTSD一旦形成后很难治愈，早期识别与进行有效的干预是治疗的关键。围创伤期个体的认知、情绪、生理与行为都发生极大的变化，这一时期的机体反应可能对PTSD的形成有一定的预测作用。研究围创伤期特定的行为反应对PTSD形成的预测作用并进行针对性的干预对防治PTSD具有重要的意义。本研究采用高强度的足电击建立大鼠PTSD动物模型，以经历电击后在陌生情境中高警戒行为作为高唤醒的指标，研究围创伤期的高唤醒对PTSD不同类型症状形成的预测作用。并进一步考察围创伤期注射阿片受体激动剂吗啡对高唤醒状态的影响以及对PTSD形成的作用。研究结果表明，(1)围创伤期的唤醒程度与电击强度正相关，高强度的电击(1.5mA,3.0mA)才能引起围创伤期异常的高唤醒。围创伤期的高唤醒程度能够预测创伤经历后早期(1周)大鼠条件性恐惧反应及陌生情境的回避行为；并且可以预测创伤经历后晚期(4周)的条件性恐惧反应；(2)经历不同可回避程度的电击后，围创伤期的高唤醒程度能够预测创伤经历后早期(1周)及晚期(4周)大鼠对陌生情境和陌生同类的回避行为、陌生环境中高警戒行为及条件性恐惧反应；(3)围创伤期连续三天吗啡处理对动物的在陌生环境中的高警戒行为没有影响，但大剂量(10mg/kg)与小剂量(1mg/kg)吗啡处理仍然在一定程度上减轻了创伤经历后大鼠的回避学习、对陌生情境和陌生同类的回避行为。本研究结果表明围创伤期的高唤醒状态可以一定程度预测动物创伤经历后晚期PTSD样行为的再体验症状，吗啡对围创伤期的高唤醒状态无明显作用，但可以一定程度减轻动物创伤经历后PTSD样行为的回避症状。此外，本研究结果提示PTSD不同症状发展形成存在不平衡性，可能具有不同的行为与神经生物学基础。 |
| 英文摘要 | Posttraumatic stress disorder (PTSD) is one of the major mental disorders that undermine people’s health. Since effective treatment of PTSD is rare, the prevention of its formation is crucial. In the peritraumatic period, cognitive, emotional and behavioral changes occurred inside the body, which may predict the formation of PTSD. Thus, to investigate the relationship between peritraumatic response and PTSD symptoms may contribute to the prediction and prevention of PTSD. This study established PTSD model in rats by high strength footshock. Using hypervigilance in novel environment as an indicator of hyperarousal, the role of peritraumatic hyperarousal in the prediction of various PTSD symptoms is explored. Besides, the study examined the effect of peritraumatic period morphine injection on preventing the development of PTSD symptoms. The major research findings are as follows. Firstly, peritraumatic hyperarousal positively related with the strength of stress, and only high stress (1.5mA, 3.0mA) induced hyperarousal disturbance. The level of peritraumatic hyperarousal could predict the early stage (1 week) conditional fear response and avoidance to novel environment and the late stage (4 weeks) conditional fear response. Secondly, the peritraumatic hyperarousal caused by stress with different avoidable possibilities could predict the early stage (1 week) and late stage (4 weeks) avoidance to novel environment and the strange others, hypervigilance in novel environment and conditional fear response. Thirdly, three-day morphine injection during peritraumatic period showed no significant influence on the hypervigilance behaviors. However, both high dose (10mg/kg) and low dose (1mg/kg) morphine somehow reduced avoidance learning and the avoidance behavior of novel environment and another strange rat. The results indicate that peritraumatic hyperarousal predicts the re-experiencing symptoms of PTSD. Although morphine fails to affect peritraumatic hyperarousal, it attenuates avoidance symptoms of PTSD. In addition, the results suggest the imbalance of PTSD-symptom development, which indicates that these different symptoms may base on different neurobiological mechanisms. |
| 学科主题 | 医学心理学 |
| 语种 | 中文 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/20374]  |
| 专题 | 心理研究所_健康与遗传心理学研究室 |
| 作者单位 | 中国科学院心理研究所 |
| 推荐引用方式 GB/T 7714 | 王慧颖. 围创伤期高唤醒对大鼠PTSD症状形成的预测作用[D]. 北京. 中国科学院研究生院. 2011. |
入库方式： OAI收割
来源：心理研究所
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