Altered Brain Activities Associated with Neural Repetition Effects in Mild Cognitive Impairment Patients
文献类型：期刊论文
| 作者 | Yu, Jing1,3 ; Li, Rui1; Jiang, Yang2; Broster, Lucas S.2; Li, Juan1,4; Li, J
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| 刊名 | JOURNAL OF ALZHEIMERS DISEASE
 |
| 出版日期 | 2016 |
| 卷号 | 53期号:2页码:693-704 |
| 通讯作者邮箱 | lijuan@psych.ac.cn |
| 关键词 | Delayed-match-to-sample task functional MRI mild cognitive impairment repetition repetition suppression |
| ISSN号 | 1387-2877 |
| 通讯作者 | Li, J |
| 英文摘要 | Older adults with mild cognitive impairment (MCI) manifest impaired explicit memory. However, studies on implicit memory such as repetition effects in persons with MCI have been limited. In the present study, 17 MCI patients and 16 healthy normal controls (NC) completed a modified delayed-match-to-sample task while undergoing functional magnetic resonance imaging. We aim to examine the neural basis of repetition; specifically, to elucidate whether and how repetition-related brain responses are altered in participants with MCI. When repeatedly rejecting distracters, both NC and MCI showed similar behavioral repetition effects; however, in both whole-brain and region-of-interest analyses of functional data, persons with MCI showed reduced repetition-driven suppression in the middle occipital and middle frontal gyrus. Further, individual difference analysis found that activation in the left middle occipital gyrus was positively correlated with rejecting reaction time and negatively correlated with accuracy rate, suggesting a predictor of repetition behavioral performance. These findings provide new evidence to support the view that neural mechanisms of repetition effect are altered in MCI who manifests compensatory repetition-related brain activities along with their neuropathology. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 学科主题 | 老年心理学 |
| 类目[WOS] | Neurosciences |
| 研究领域[WOS] | Neurosciences & Neurology |
| 关键词[WOS] | DEFAULT-MODE NETWORK ; EVENT-RELATED FMRI ; ALZHEIMERS-DISEASE ; IMPLICIT MEMORY ; WORKING-MEMORY ; FUNCTIONAL CONNECTIVITY ; RECOGNITION MEMORY ; HIPPOCAMPAL ; MCI ; METAANALYSIS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000381207500025 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/20366]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Li, J |
| 作者单位 | 1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Ctr Aging Psychol, Beijing, Peoples R China 2.Univ Kentucky, Coll Med, Lexington, KY USA 3.Southwest Univ, Fac Psychol, Chongqing, Peoples R China 4.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu, Jing,Li, Rui,Jiang, Yang,et al. Altered Brain Activities Associated with Neural Repetition Effects in Mild Cognitive Impairment Patients[J]. JOURNAL OF ALZHEIMERS DISEASE,2016,53(2):693-704. |
| APA | Yu, Jing,Li, Rui,Jiang, Yang,Broster, Lucas S.,Li, Juan,&Li, J.(2016).Altered Brain Activities Associated with Neural Repetition Effects in Mild Cognitive Impairment Patients.JOURNAL OF ALZHEIMERS DISEASE,53(2),693-704. |
| MLA | Yu, Jing,et al."Altered Brain Activities Associated with Neural Repetition Effects in Mild Cognitive Impairment Patients".JOURNAL OF ALZHEIMERS DISEASE 53.2(2016):693-704. |
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来源：心理研究所
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