Differential mesolimbic and prefrontal alterations during reward anticipation and consummation in positive and negative schizotypy
文献类型：期刊论文
| 作者 | Yan, Chao1,2 ; Wang, Yi2; Su, Li3; Xu, Ting2; Yin, Da-zhi4; Fan, Ming-xia5; Deng, Ci-ping1; Wang, Zhao-xin1; Lui, Simon S. Y.2,6; Cheung, Eric F. C.6
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| 刊名 | PSYCHIATRY RESEARCH-NEUROIMAGING
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| 出版日期 | 2016-08-30 |
| 卷号 | 254期号:0页码:127-136 |
| 通讯作者邮箱 | ckchan@psych.ac.cn |
| 关键词 | Negative schizotypy Positive schizotypy fMRI Reward anticipation Reward consummation |
| ISSN号 | 0925-4927 |
| 通讯作者 | Chan, Raymond C. K. |
| 英文摘要 | Schizotypy is associated with anhedonia. However, previous findings on the neural substrates of anhedonia in schizotypy are mixed. In the present study, we measured the neural substrates associated with reward anticipation and consummation in positive and negative schizotypy using functional MRI. The Monetary Incentive Delay task was administered to 33 individuals with schizotypy (18 positive schizotypy (P5),15 negative schizotypy (NS)) and 22 healthy controls. Comparison between schizotypy individuals and controls were performed using two-sample T tests for contrast images involving gain versus non-gain anticipation condition and gain versus non-gain consummation condition. Multiple comparisons were corrected using Monte Carlo Simulation correction of p < .05. The results showed no significant difference in brain activity between controls and schizotypy individuals as a whole during gain anticipation or consummation. However, during the consummatory phase, NS individuals rather than PS individuals showed diminished left amygdala and left putamen activity compared with controls. We observed significantly weaker activation at the left ventral striatum during gain anticipation in NS individuals compared with controls. PS individuals, however, exhibited enhanced right ventral lateral prefrontal activity. These findings suggest that different dimensions of schizotypy may be underlied by different neural dysfunctions in reward anticipation and consummation. (C) 2016 Elsevier Ireland Ltd. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Clinical Neurology ; Neuroimaging ; Psychiatry |
| 研究领域[WOS] | Neurosciences & Neurology ; Psychiatry |
| 关键词[WOS] | UNAFFECTED SIBLINGS ; NUCLEUS-ACCUMBENS ; SOCIAL ANHEDONIA ; SCHIZOPHRENIA ; EMOTION ; EXPERIENCE ; FMRI ; PERSONALITY ; EXPRESSION ; PSYCHOSIS |
| 收录类别 | SCI ; SSCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000382316000017 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/20395]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 作者单位 | 1.East China Normal Univ, Shanghai Key Lab Brain Funct Genom MOE STCSM, Minist Educ, Key Lab Brain Funct Genom, Shanghai, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing, Peoples R China 3.Univ Cambridge, Dept Psychiat, Cambridge Biomed Campus, Cambridge, England 4.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai, Peoples R China 5.East China Normal Univ, Shanghai Key Lab MRI, Shanghai, Peoples R China 6.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yan, Chao,Wang, Yi,Su, Li,et al. Differential mesolimbic and prefrontal alterations during reward anticipation and consummation in positive and negative schizotypy[J]. PSYCHIATRY RESEARCH-NEUROIMAGING,2016,254(0):127-136. |
| APA | Yan, Chao.,Wang, Yi.,Su, Li.,Xu, Ting.,Yin, Da-zhi.,...&Chan, Raymond C. K..(2016).Differential mesolimbic and prefrontal alterations during reward anticipation and consummation in positive and negative schizotypy.PSYCHIATRY RESEARCH-NEUROIMAGING,254(0),127-136. |
| MLA | Yan, Chao,et al."Differential mesolimbic and prefrontal alterations during reward anticipation and consummation in positive and negative schizotypy".PSYCHIATRY RESEARCH-NEUROIMAGING 254.0(2016):127-136. |
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来源：心理研究所
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