Neural Substrates of the Impaired Effort Expenditure Decision Making in Schizophrenia
文献类型：期刊论文
| 作者 | Huang, Jia1 ; Yang, Xin-hua1,2; Lan, Yong2; Zhu, Cui-ying2; Liu, Xiao-qun3; Wang, Ye-fei4; Cheung, Eric F. C.5; Xie, Guang-rong4; Chan, Raymond C. K.1
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| 刊名 | NEUROPSYCHOLOGY
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| 出版日期 | 2016-09-01 |
| 卷号 | 30期号:6页码:685-696 |
| 通讯作者邮箱 | rckchan@psych.ac.cn |
| 关键词 | effort expenditure for reward task motivation schizophrenia fMRI |
| ISSN号 | 0894-4105 |
| 通讯作者 | Chan, Raymond C. K. |
| 英文摘要 | Objective: Unwillingness to expend more effort to pursue high value rewards has been associated with motivational anhedonia in schizophrenia (SCZ) and abnormal dopamine activity in the nucleus accumbens (NAcc). The authors hypothesized that dysfunction of the NAcc and the associated forebrain regions are involved in the impaired effort expenditure decision-making of SCZ. Method: A 2 (reward magnitude: low vs. high) x 3 (probability: 20% vs. 50% vs. 80%) event-related fMRI design in the effort-expenditure for reward task (EEfRT) was used to examine the neural response of 23 SCZ patients and 23 demographically matched control participants when the participants made effort expenditure decisions to pursue uncertain rewards. Results: SCZ patients were significantly less likely to expend high level of effort in the medium (50%) and high (80%) probability conditions than healthy controls. The neural response in the NAcc, the posterior cingulate gyrus and the left medial frontal gyrus in SCZ patients were weaker than healthy controls and did not linearly increase with an increase in reward magnitude and probability. Moreover, NAcc activity was positively correlated with the willingness to expend high-level effort and concrete consummatory pleasure experience. Conclusion: NAcc and posterior cingulate dysfunctions in SCZ patients may be involved in their impaired effort expenditure decision-making. |
| WOS标题词 | Social Sciences ; Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Psychology, Clinical ; Neurosciences ; Psychology |
| 研究领域[WOS] | Psychology ; Neurosciences & Neurology |
| 关键词[WOS] | POSTERIOR CINGULATE CORTEX ; NEGATIVE SYMPTOMS ; MOTIVATIONAL DEFICITS ; EFFORT COMPUTATION ; EFFORT ALLOCATION ; REWARDS TASK ; HUMAN BRAIN ; ANHEDONIA ; DOPAMINE ; PLEASURE |
| 收录类别 | SCI ; SSCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000383879300004 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/20464]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Neuropsychol & Appl Cognit Neurosci Lab, Key Lab Mental Hlth, Inst Psychol, Hong Kong, Hong Kong, Peoples R China 2.Hunan Agr Univ, Inst Educ, Rural Children & Adolescents Res Ctr Hlth Promot, Hong Kong, Hong Kong, Peoples R China 3.Cent S Univ, Sch Publ Hlth, Hong Kong, Hong Kong, Peoples R China 4.Cent S Univ, Natl Technol Inst Psychiat, Key Lab Psychiat & Mental Hlth Hunan Prov, Mental Hlth Inst,Xiangya Hosp 2, Hong Kong, Hong Kong, Peoples R China 5.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Jia,Yang, Xin-hua,Lan, Yong,et al. Neural Substrates of the Impaired Effort Expenditure Decision Making in Schizophrenia[J]. NEUROPSYCHOLOGY,2016,30(6):685-696. |
| APA | Huang, Jia.,Yang, Xin-hua.,Lan, Yong.,Zhu, Cui-ying.,Liu, Xiao-qun.,...&Chan, Raymond C. K..(2016).Neural Substrates of the Impaired Effort Expenditure Decision Making in Schizophrenia.NEUROPSYCHOLOGY,30(6),685-696. |
| MLA | Huang, Jia,et al."Neural Substrates of the Impaired Effort Expenditure Decision Making in Schizophrenia".NEUROPSYCHOLOGY 30.6(2016):685-696. |
入库方式： OAI收割
来源：心理研究所
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