Cognitive dysfunction and epigenetic alterations of the BDNF gene are induced by social isolation during early adolescence
文献类型：期刊论文
| 作者 | Li, Man1; Du, Wei1; Shao, Feng1; Wang, Weiwen2
|
| 刊名 | BEHAVIOURAL BRAIN RESEARCH
 |
| 出版日期 | 2016-10-15 |
| 卷号 | 313期号:0页码:177-183 |
| 通讯作者邮箱 | shaof@pku.edu.cn ; wangww@psych.ac.cn |
| ISSN号 | 0166-4328 |
| 关键词 | Social isolation Cognitive behaviour Brain-derived neurotrophic factor (BDNF) Epigenetics |
| 通讯作者 | Shao, Feng ; Wang, Weiwen |
| 英文摘要 | Early life adversity, such as social isolation, causes a variety of changes to the development of cognitive abilities and the nervous system. Increasing evidence has shown that epigenetic modifications mediate gene-environment interactions throughout the lifespan. In this study, we investigated the effect of adolescent social isolation on cognitive behaviours and epigenetic alterations of the brain-derived neurotrophic factor (BDNF) gene. Male Sprague Dawley rats were randomly assigned to either group reared or isolation-reared conditions during post-natal days (PNDs) 21-34. On PND 56, all rats underwent behavioural testing and were then sacrificed for biochemical testing. Adolescent social isolation induced impaired PPI. Regarding BDNF, the isolation-reared rats demonstrated increased BDNF mRNA levels, H3 acetylation at the BDNF gene and BDNF protein expression in the medial prefrontal cortex (mPFC). In contrast, the BDNF mRNA levels, H3 acetylation of the BDNF gene and BDNF protein expression were decreased in the hippocampus of the isolation-reared rats. The present study indicated that epigenetic regulation of BDNF may be one of the molecular mechanisms that mediated the cognitive dysfunction. Moreover, the interaction between the mPFC and hippocampus might play an important role in the regulation of cognitive behaviour. (C) 2016 Elsevier B.V. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Behavioral Sciences ; Neurosciences |
| 研究领域[WOS] | Behavioral Sciences ; Neurosciences & Neurology |
| 关键词[WOS] | MEDIAL PREFRONTAL CORTEX ; NEUROTROPHIC FACTOR EXPRESSION ; SPATIAL MEMORY PERFORMANCE ; ACOUSTIC STARTLE RESPONSE ; PREPULSE INHIBITION ; ADULT RATS ; MATERNAL SEPARATION ; VENTRAL HIPPOCAMPUS ; THETA-OSCILLATIONS ; NUCLEUS-ACCUMBENS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000382413800021 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/20535]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 作者单位 | 1.Peking Univ, Beijing Key Lab Behav & Mental Hlth, Sch Psychol & Cognit Sci, 5 Yiheyuan Rd, Beijing 100871, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Man,Du, Wei,Shao, Feng,et al. Cognitive dysfunction and epigenetic alterations of the BDNF gene are induced by social isolation during early adolescence[J]. BEHAVIOURAL BRAIN RESEARCH,2016,313(0):177-183. |
| APA | Li, Man,Du, Wei,Shao, Feng,&Wang, Weiwen.(2016).Cognitive dysfunction and epigenetic alterations of the BDNF gene are induced by social isolation during early adolescence.BEHAVIOURAL BRAIN RESEARCH,313(0),177-183. |
| MLA | Li, Man,et al."Cognitive dysfunction and epigenetic alterations of the BDNF gene are induced by social isolation during early adolescence".BEHAVIOURAL BRAIN RESEARCH 313.0(2016):177-183. |
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来源：心理研究所
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