A Triple Network Connectivity Study of Large-Scale Brain Systems in Cognitively Normal APOE4 Carriers
文献类型：期刊论文
| 作者 | Wu, Xia1,2; Li, Qing1; Yu, Xinyu1; Chen, Kewei3,4; Fleisher, Adam S.3,4,5; Guo, Xiaojuan1; Zhang, Jiacai1; Reiman, Eric M.3,4; Yao, Li1,2; Li, Rui6
|
| 刊名 | FRONTIERS IN AGING NEUROSCIENCE
 |
| 出版日期 | 2016-09-28 |
| 卷号 | 8期号:0页码:1-9 |
| 通讯作者邮箱 | lir@psych.ac.cn |
| 关键词 | Alzheimer's Disease APOE4 Bayesian network connectivity fMRI triple network model |
| ISSN号 | 1663-4365 |
| 通讯作者 | Li, Rui |
| 英文摘要 | The triple network model, consisting of the central executive network (CEN), salience network (SN) and default mode network (DMN), has been recently employed to understand dysfunction in core networks across various disorders. Here we used the triple network model to investigate the large-scale brain networks in cognitively normal apolipoprotein e4 (APOE4) carriers who are at risk of Alzheimers disease (AD). To explore the functional connectivity for each of the three networks and the effective connectivity among them, we evaluated 17 cognitively normal individuals with a family history of AD and at least one copy of the APOE4 allele and compared the findings to those of 12 individuals who did not carry the APOE4 gene or have a family history of AD, using independent component analysis (ICA) and Bayesian network (BN) approach. Our findings indicated altered within-network connectivity that suggests future cognitive decline risk, and preserved between-network connectivity that may support their current preserved cognition in the cognitively normal APOE4 allele carriers. The study provides novel sights into our understanding of the risk factors for AD and their influence on the triple network model of major psychopathology. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Geriatrics & Gerontology ; Neurosciences |
| 研究领域[WOS] | Geriatrics & Gerontology ; Neurosciences & Neurology |
| 关键词[WOS] | DEFAULT-MODE NETWORK ; INDEPENDENT COMPONENT ANALYSIS ; RESTING-STATE FMRI ; ALZHEIMERS-DISEASE ; FUNCTIONAL CONNECTIVITY ; FRONTOTEMPORAL DEMENTIA ; IMPAIRMENT ; MEMORY ; RISK ; MRI |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000384137400001 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/20541]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 作者单位 | 1.Beijing Normal Univ, Coll Informat Sci & Technol, Beijing, Peoples R China 2.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing, Peoples R China 3.Banner Alzheimers Inst, Phoenix, AZ USA 4.Banner Good Samaritan PET Ctr, Phoenix, AZ USA 5.Eli Lilly & Co, Indianapolis, IN 46285 USA 6.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Ctr Aging Psychol, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Xia,Li, Qing,Yu, Xinyu,et al. A Triple Network Connectivity Study of Large-Scale Brain Systems in Cognitively Normal APOE4 Carriers[J]. FRONTIERS IN AGING NEUROSCIENCE,2016,8(0):1-9. |
| APA | Wu, Xia.,Li, Qing.,Yu, Xinyu.,Chen, Kewei.,Fleisher, Adam S..,...&Li, Rui.(2016).A Triple Network Connectivity Study of Large-Scale Brain Systems in Cognitively Normal APOE4 Carriers.FRONTIERS IN AGING NEUROSCIENCE,8(0),1-9. |
| MLA | Wu, Xia,et al."A Triple Network Connectivity Study of Large-Scale Brain Systems in Cognitively Normal APOE4 Carriers".FRONTIERS IN AGING NEUROSCIENCE 8.0(2016):1-9. |
入库方式： OAI收割
来源：心理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。