Increasing Pain Sensation Eliminates the Inhibitory Effect of Depression on Evoked Pain in Rats
文献类型：期刊论文
| 作者 | Wang, Ning1 ; Li, Sheng-Guang1; Lin, Xiao-Xiao1,2; Su, Yuan-Lin1; Qi, Wei-Jing1; Wang, Jin-Yan1,2; Luo, Fei1,2
|
| 刊名 | FRONTIERS IN BEHAVIORAL NEUROSCIENCE
 |
| 出版日期 | 2016-09-28 |
| 卷号 | 10期号:0页码:1-12 |
| 通讯作者邮箱 | wangjy@psych.ac.cn |
| 关键词 | unpredictable chronic mild stress pain serotonin descending inhibition avoidance motivation |
| ISSN号 | 1662-5153 |
| 通讯作者 | Wang, Jin-Yan |
| 英文摘要 | Although previous studies have suggested that depression may be associated with inhibition of evoked pain but facilitation of spontaneous pain, the mechanisms underlying these relationships are unclear. The present study investigated whether the difference between evoked and spontaneous pain on sensory (descending inhibition) and affective (avoidance motivation) components contributes to the divergent effects of depression on them. Depressive-like behavior was produced in male Wistar rats by unpredictable chronic mild stress (UCMS). Tone-laser conditioning and formalin-induced conditioned place avoidance (F-CPA) were used to explore avoidance motivation in evoked and spontaneous pain, respectively. Behavioral pharmacology experiments were conducted to examine descending inhibition of both evoked (thermal stimulation) and spontaneous pain behavior (formalin pain). The results revealed that the inhibitory effect of depression on evoked pain was eliminated following repeated thermal stimuli. Avoidance behavior in the tone-laser conditioning task was reduced in UCMS rats, relative to controls. However, avoidance motivation for formalin pain in the UCMS group was similar to controls. 5-HT1A receptor antagonism interfered with inhibition of pain responses over time. The present study demonstrated that the inhibitory effect of depression on evoked pain dissipates with increased nociception and that the sensory-discriminative and affective-motivational components of pain are jointly involved in the divergent effects of depression on pain. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Behavioral Sciences ; Neurosciences |
| 研究领域[WOS] | Behavioral Sciences ; Neurosciences & Neurology |
| 关键词[WOS] | ANTERIOR CINGULATE CORTEX ; FRONTAL EEG ASYMMETRY ; CUTANEOUS HYPERALGESIA ; BEHAVIORAL ACTIVATION ; AFFECTIVE COMPONENT ; MAJOR DEPRESSION ; SEROTONIN SYSTEM ; AVOIDANCE GOALS ; MILD STRESS ; PERCEPTION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000384048600002 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/20543]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Ning,Li, Sheng-Guang,Lin, Xiao-Xiao,et al. Increasing Pain Sensation Eliminates the Inhibitory Effect of Depression on Evoked Pain in Rats[J]. FRONTIERS IN BEHAVIORAL NEUROSCIENCE,2016,10(0):1-12. |
| APA | Wang, Ning.,Li, Sheng-Guang.,Lin, Xiao-Xiao.,Su, Yuan-Lin.,Qi, Wei-Jing.,...&Luo, Fei.(2016).Increasing Pain Sensation Eliminates the Inhibitory Effect of Depression on Evoked Pain in Rats.FRONTIERS IN BEHAVIORAL NEUROSCIENCE,10(0),1-12. |
| MLA | Wang, Ning,et al."Increasing Pain Sensation Eliminates the Inhibitory Effect of Depression on Evoked Pain in Rats".FRONTIERS IN BEHAVIORAL NEUROSCIENCE 10.0(2016):1-12. |
入库方式： OAI收割
来源：心理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。