Genetic Effects on Fine-Grained Human Cortical Regionalization
文献类型：期刊论文
| 作者 | Cui, Yue1,2; Liu, Bing1,2; Zhou, Yuan4,5 ; Fan, Lingzhong1,2; Li, Jin1,2; Zhang, Yun6; Wu, Huawang6,7; Hou, Bing1,2; Wang, Chao6; Zheng, Fanfan1,2
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| 刊名 | CEREBRAL CORTEX
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| 出版日期 | 2016-09-01 |
| 卷号 | 26期号:9页码:3732-3743 |
| 通讯作者邮箱 | jiangtz@nlpr.ia.ac.cn ; lishu@psych.ac.cn |
| 关键词 | cortical regionalization genetic correlation genetics surface area twins |
| ISSN号 | 1047-3211 |
| 通讯作者 | Jiang, Tianzi ; Li, Shu |
| 英文摘要 | Various brain structural and functional features such as cytoarchitecture, topographic mapping, gyral/sulcal anatomy, and anatomical and functional connectivity have been used in human brain parcellation. However, the fine-grained intrinsic genetic architecture of the cortex remains unknown. In the present study, we parcellated specific regions of the cortex into subregions based on genetic correlations (i.e., shared genetic influences) between the surface area of each pair of cortical locations within the seed region. The genetic correlations were estimated by comparing the correlations of the surface area between monozygotic and dizygotic twins using bivariate twin models. Our genetic subdivisions of diverse brain regions were reproducible across 2 independent datasets and corresponded closely to fine-grained functional specializations. Furthermore, subregional genetic correlation profiles were generally consistent with functional connectivity patterns. Our findings indicate that the magnitude of the genetic covariance in brain anatomy could be used to delineate the boundaries of functional subregions of the brain and may be of value in the next generation human brain atlas. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Neurosciences |
| 研究领域[WOS] | Neurosciences & Neurology |
| 关键词[WOS] | HUMAN CEREBRAL-CORTEX ; CONNECTIVITY-BASED PARCELLATION ; SUPPLEMENTARY MOTOR AREAS ; SURFACE-BASED ANALYSIS ; FRONTAL-CORTEX ; BROCAS REGION ; HUMAN BRAIN ; FUNCTIONAL LOCALIZATION ; PREFRONTAL CORTEX ; WORKING-MEMORY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000384668600006 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/20527]  |
| 专题 | 心理研究所_中国科学院行为科学重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China 3.Chinese Acad Sci, CAS Ctr Excellence Brain Sci, Inst Automat, Beijing 100190, Peoples R China 4.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China 5.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing 100101, Peoples R China 6.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Key Lab NeuroInformat, Minist Educ, Chengdu 610054, Peoples R China 7.Guangzhou Med Univ, Affiliated Brain Hosp, Guangzhou Brain Hosp, Guangzhou 510370, Guangdong, Peoples R China 8.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia |
| 推荐引用方式 GB/T 7714 | Cui, Yue,Liu, Bing,Zhou, Yuan,et al. Genetic Effects on Fine-Grained Human Cortical Regionalization[J]. CEREBRAL CORTEX,2016,26(9):3732-3743. |
| APA | Cui, Yue.,Liu, Bing.,Zhou, Yuan.,Fan, Lingzhong.,Li, Jin.,...&Jiang, Tianzi.(2016).Genetic Effects on Fine-Grained Human Cortical Regionalization.CEREBRAL CORTEX,26(9),3732-3743. |
| MLA | Cui, Yue,et al."Genetic Effects on Fine-Grained Human Cortical Regionalization".CEREBRAL CORTEX 26.9(2016):3732-3743. |
入库方式： OAI收割
来源：心理研究所
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