UPLC-QTOFMS(E)-Guided Dereplication of the Endangered Chinese Species Garcinia paucinervis to Identify Additional Benzophenone Derivatives
文献类型：期刊论文
| 作者 | Li, Ping1; Senthilkumar, Harini Anandhi4; Figueroa, Mario5; Wu, Shi-Biao2; Fata, Jimmie E.3,4; Kennelly, Edward J.1,2,4; Long, Chunlin1,6 |
| 刊名 | JOURNAL OF NATURAL PRODUCTS
 |
| 出版日期 | 2016-06-01 |
| 卷号 | 79期号:6页码:1619-1627 |
| 英文摘要 | A number of Garcinia species accumulate benzophenone derivatives that may be useful for the treatment of breast cancer. The dereplication of new benzophenone derivatives from Garcinia species is challenging due to the occurrence of multiple isomers and the known compounds found in their extracts. In the current study, a strategy is described using the UPLC-QTOFMS(E) technique to identify tentatively the known and uncharacterized benzophenones of interest based upon the characteristic fragmentation ions. Several UPLC-QTOFMS peaks (a-ee) appeared to contain benzophenone derivatives, and 12 of these peaks contained compounds with MS ionization profiles not consistent with previously identified compounds from the seeds of Garcinia paucinervis, an endangered Chinese species. The targeted isolation of unidentified compounds of interest afforded five new benzophenones, paucinones E-I (1-5), which were determined by MS and NMR analysis and ECD spectroscopy. These compounds were evaluated for cytotoxicity against three breast cancer cell lines inclusive of MDA-MB-231, SKBR3, and MCF-7. These results indicate that the UPLC-QTOFMS(E)-guided isolation procedure is an efficient strategy for isolating new benzophenones from Garcinia species. |
| 类目[WOS] | Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 研究领域[WOS] | Plant Sciences ; Pharmacology & Pharmacy |
| 关键词[WOS] | POLYCYCLIC POLYPRENYLATED ACYLPHLOROGLUCINOLS ; PERFORMANCE LIQUID-CHROMATOGRAPHY ; ELECTRONIC CIRCULAR-DICHROISM ; FLIGHT MASS-SPECTROMETRY ; COLON-CANCER CELLS ; POLYISOPRENYLATED BENZOPHENONES ; ELECTROSPRAY-IONIZATION ; ANALYTICAL STRATEGY ; PHENOLIC-COMPOUNDS ; NATURAL-PRODUCTS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000378758200017 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/26296]  |
| 专题 | 昆明植物研究所_离退休 |
| 作者单位 | 1.Minzu Univ China, Coll Life & Environm Sci, Beijing 100081, Peoples R China 2.CUNY, Lehman Coll, Dept Biol Sci, Bronx, NY 10468 USA 3.CUNY Coll Staten Isl, Dept Biol Sci, Staten Isl, NY 10314 USA 4.CUNY, Grad Ctr, Biochem Biol & Chem PhD Programs, New York, NY 10016 USA 5.Univ Nacl Autonoma Mexico, Fac Quim, Mexico City 04510, DF, Mexico 6.Chinese Acad Sci, Kunming Inst Bot, Kunming 650201, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Ping,Senthilkumar, Harini Anandhi,Figueroa, Mario,et al. UPLC-QTOFMS(E)-Guided Dereplication of the Endangered Chinese Species Garcinia paucinervis to Identify Additional Benzophenone Derivatives[J]. JOURNAL OF NATURAL PRODUCTS,2016,79(6):1619-1627. |
| APA | Li, Ping.,Senthilkumar, Harini Anandhi.,Figueroa, Mario.,Wu, Shi-Biao.,Fata, Jimmie E..,...&Long, Chunlin.(2016).UPLC-QTOFMS(E)-Guided Dereplication of the Endangered Chinese Species Garcinia paucinervis to Identify Additional Benzophenone Derivatives.JOURNAL OF NATURAL PRODUCTS,79(6),1619-1627. |
| MLA | Li, Ping,et al."UPLC-QTOFMS(E)-Guided Dereplication of the Endangered Chinese Species Garcinia paucinervis to Identify Additional Benzophenone Derivatives".JOURNAL OF NATURAL PRODUCTS 79.6(2016):1619-1627. |
入库方式： OAI收割
来源：昆明植物研究所
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