LC-MS-Guided Isolation of Penicilfuranone A: A New Antifibrotic Furancarboxylic Acid from the Plant Endophytic Fungus Penicillium sp sh18
文献类型：期刊论文
| 作者 | Wang, Wei-Guang1; Li, Ao2; Yan, Bing-Chao1,3; Niu, Shu-Bin4; Tang, Jian-Wei1,3; Li, Xiao-Nian1; Du, Xue1; Challis, Gregory L.5; Che, Yongsheng4; Sung, Han-Dong1
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| 刊名 | JOURNAL OF NATURAL PRODUCTS
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| 出版日期 | 2016 |
| 卷号 | 79期号:1页码:149-155 |
| 英文摘要 | Penicilfuranone A (1), a novel furancarboxylic acid, and its proposed biosynthetic precursor, gregatin A (2), were isolated from the cultures of the fungus Penicillium sp. sh18 endophytic to the stems of Isodon eriocalyx var. laxiflora guided by HPLC-MS. X-ray crystallography was applied to the structure determination of furancarboxylic acid for the first time, allowing unambiguous assignment of 1. Penicilfuranone A displays a significant antifibrotic effect in activated hepatic stellate cells via negative regulation of transforming growth factor-beta (TGF-beta)/Smad signaling. |
| 类目[WOS] | Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 研究领域[WOS] | Plant Sciences ; Pharmacology & Pharmacy |
| 关键词[WOS] | HEPATIC STELLATE CELLS ; NATURAL-PRODUCTS ; ASPERTETRONIN-A ; LIVER FIBROSIS ; (+)-GREGATIN B ; TGF-BETA ; GRAMININ ; DERIVATIVES ; GREGATINS ; CARBANIONS |
| 收录类别 | SCI ; IC |
| 语种 | 英语 |
| WOS记录号 | WOS:000368755000019 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/25943]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Chongqing Univ Technol, Coll Pharm & Bioengn, Chongqing 400054, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Beijing Inst Pharmacol & Toxicol, State Key Lab Toxicol & Med Countermeasures, Beijing 100850, Peoples R China 5.Univ Warwick, Dept Chem, Coventry CV4 7AL, W Midlands, England |
| 推荐引用方式 GB/T 7714 | Wang, Wei-Guang,Li, Ao,Yan, Bing-Chao,et al. LC-MS-Guided Isolation of Penicilfuranone A: A New Antifibrotic Furancarboxylic Acid from the Plant Endophytic Fungus Penicillium sp sh18[J]. JOURNAL OF NATURAL PRODUCTS,2016,79(1):149-155. |
| APA | Wang, Wei-Guang.,Li, Ao.,Yan, Bing-Chao.,Niu, Shu-Bin.,Tang, Jian-Wei.,...&Pu, Jian-Xin.(2016).LC-MS-Guided Isolation of Penicilfuranone A: A New Antifibrotic Furancarboxylic Acid from the Plant Endophytic Fungus Penicillium sp sh18.JOURNAL OF NATURAL PRODUCTS,79(1),149-155. |
| MLA | Wang, Wei-Guang,et al."LC-MS-Guided Isolation of Penicilfuranone A: A New Antifibrotic Furancarboxylic Acid from the Plant Endophytic Fungus Penicillium sp sh18".JOURNAL OF NATURAL PRODUCTS 79.1(2016):149-155. |
入库方式： OAI收割
来源：昆明植物研究所
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