N-Hydroxyphthalimide exhibits antitumor activity by suppressing mTOR signaling pathway in BT-20 and LoVo cells
文献类型：期刊论文
| 作者 | Wang, Min1,2; Zhou, Ankun1; An, Tao1,2 ; Kong, Lingmei1; Yu, Chunlei1,2; Liu, Jianmei1; Xia, Chengfeng1; Zhou, Hongyu1; Li, Yan1
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| 刊名 | JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
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| 出版日期 | 2016-03-03 |
| 卷号 | 35 |
| 关键词 | N-Hydroxyphthalimide mTOR Inhibitor Cancer Mitochondrial apoptosis |
| 英文摘要 | Background: N-Hydroxyphthalimide (NHPI), an important chemical raw material, was found to have potent and selective anti-proliferative effect on human breast carcinoma BT-20 cells, human colon adenocarcinoma LoVo and HT-29 cells during our screening for anticancer compounds. The purpose of this study is to assess the antitumor efficacy of NHPI in vitro and in vivo and to explore the underlying antitumor mechanism. |
| 类目[WOS] | Oncology |
| 研究领域[WOS] | Oncology |
| 关键词[WOS] | CANCER-THERAPY ; MITOCHONDRIAL APOPTOSIS ; SURVIVIN EXPRESSION ; IN-VITRO ; INHIBITORS ; GROWTH ; RAPAMYCIN ; RESISTANCE ; KINASE ; PI3K |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000371383700001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/26003]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Min,Zhou, Ankun,An, Tao,et al. N-Hydroxyphthalimide exhibits antitumor activity by suppressing mTOR signaling pathway in BT-20 and LoVo cells[J]. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH,2016,35. |
| APA | Wang, Min.,Zhou, Ankun.,An, Tao.,Kong, Lingmei.,Yu, Chunlei.,...&Li, Yan.(2016).N-Hydroxyphthalimide exhibits antitumor activity by suppressing mTOR signaling pathway in BT-20 and LoVo cells.JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH,35. |
| MLA | Wang, Min,et al."N-Hydroxyphthalimide exhibits antitumor activity by suppressing mTOR signaling pathway in BT-20 and LoVo cells".JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH 35(2016). |
入库方式： OAI收割
来源：昆明植物研究所
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