Tropolone Ring Construction in the Biosynthesis of Rubrolone B, a Cationic Tropolone Alkaloid from Endophytic Streptomyces
文献类型：期刊论文
| 作者 | Yan, Yijun1; Ma, Ya-Tuan1; Yang, Jing1 ; Horsman, Geoff P.2; Luo, Dan1; Ji, Xu1; Huang, Sheng-Xiong1
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| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2016-03-18 |
| 卷号 | 18期号:6页码:1254-1257 |
| 英文摘要 | Rubrolones are tropolonoid natural products with a unique carbon skeleton. Extensive secondary metabolite analysis of the endophytic Streptomyces sp. KIB-H033 revealed a new class of rubrolone analogue possessing a rare benzoic acid pyridine inner salt moiety. Precursor feeding with [C-13] -acetate revealed a labeling pattern consistent with tropolone moiety construction via type-II PKS chemistry followed by complex oxidative rearrangements. This bacterial biosynthetic route represents a surprising departure from fungal tropolone assembly during stipitatic acid biosynthesis. |
| 类目[WOS] | Chemistry, Organic |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | ECHINORUBER SP-NOV ; POLYKETIDE SYNTHASES ; RED PIGMENT ; MICROORGANISMS ; BIOCHEMISTRY ; DERIVATIVES ; EXPRESSION ; MECHANISM ; PRODUCTS ; FUNGAL |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000372664600010 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/26179]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Wilfrid Laurier Univ, Dept Chem & Biochem, Waterloo, ON N2L 3C5, Canada |
| 推荐引用方式 GB/T 7714 | Yan, Yijun,Ma, Ya-Tuan,Yang, Jing,et al. Tropolone Ring Construction in the Biosynthesis of Rubrolone B, a Cationic Tropolone Alkaloid from Endophytic Streptomyces[J]. ORGANIC LETTERS,2016,18(6):1254-1257. |
| APA | Yan, Yijun.,Ma, Ya-Tuan.,Yang, Jing.,Horsman, Geoff P..,Luo, Dan.,...&Huang, Sheng-Xiong.(2016).Tropolone Ring Construction in the Biosynthesis of Rubrolone B, a Cationic Tropolone Alkaloid from Endophytic Streptomyces.ORGANIC LETTERS,18(6),1254-1257. |
| MLA | Yan, Yijun,et al."Tropolone Ring Construction in the Biosynthesis of Rubrolone B, a Cationic Tropolone Alkaloid from Endophytic Streptomyces".ORGANIC LETTERS 18.6(2016):1254-1257. |
入库方式： OAI收割
来源：昆明植物研究所
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