Iridium-Catalyzed Enantioselective Indole Cyclization: Application to the Total Synthesis and Absolute Stereochemical Assignment of (-)-AspidophyllineA
文献类型：期刊论文
| 作者 | Jiang, Shi-Zhi1; Zeng, Xue-Yi1,2; Liang, Xiao1,2; Lei, Ting1 ; Wei, Kun1; Yang, Yu-Rong1
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| 刊名 | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
 |
| 出版日期 | 2016-03-14 |
| 卷号 | 55期号:12页码:4044-4048 |
| 关键词 | cyclizations enantioselectivity indoles iridium total synthesis |
| 英文摘要 | The first enantioselective total synthesis of (-)-aspidophyllineA, including assignment of its absolute configuration has been accomplished. A key element of the synthesis is a highly enantioselective indole allylic alkylation/iminium cyclization cascade which was developed by employing a combination of Lewis acid activation and an iridium/ligand catalyst. This strategy relies on the direct use of 2,3-disubstituted indoles with secondary allylic alcohols appended at C2 and heteronucleophiles appended at C3, indoles which are easily prepared from simple starting materials under C-H activation conditions. |
| 类目[WOS] | Chemistry, Multidisciplinary |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | ALLYLIC DEAROMATIZATION REACTION ; C-H ACTIVATION ; AKUAMMILINE ALKALOIDS ; 3-SUBSTITUTED INDOLES ; ALKYLATION REACTIONS ; STRYCHNOS ALKALOIDS ; ENOL ETHERS ; ALLYLATION ; ALCOHOLS ; (+/-)-ASPIDOPHYLLINE |
| 收录类别 | SCI ; IC ; CCR |
| 语种 | 英语 |
| WOS记录号 | WOS:000372660400033 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/26181]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Lanhei 132, Kunming 650201, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiang, Shi-Zhi,Zeng, Xue-Yi,Liang, Xiao,et al. Iridium-Catalyzed Enantioselective Indole Cyclization: Application to the Total Synthesis and Absolute Stereochemical Assignment of (-)-AspidophyllineA[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2016,55(12):4044-4048. |
| APA | Jiang, Shi-Zhi,Zeng, Xue-Yi,Liang, Xiao,Lei, Ting,Wei, Kun,&Yang, Yu-Rong.(2016).Iridium-Catalyzed Enantioselective Indole Cyclization: Application to the Total Synthesis and Absolute Stereochemical Assignment of (-)-AspidophyllineA.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,55(12),4044-4048. |
| MLA | Jiang, Shi-Zhi,et al."Iridium-Catalyzed Enantioselective Indole Cyclization: Application to the Total Synthesis and Absolute Stereochemical Assignment of (-)-AspidophyllineA".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 55.12(2016):4044-4048. |
入库方式： OAI收割
来源：昆明植物研究所
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