Obscurumines H-P, new Lycopodium alkaloids from the club moss Lycopodium obscurum
文献类型：期刊论文
| 作者 | Jiang, Wei-Wei1,2; Liu, Yu-Chen1; Zhang, Zhi-Jun1; Liu, Yan-Chun1 ; He, Juan1; Su, Jia1; Cheng, Xiao1; Peng, Li-Yan1; Shao, Li-Dong1; Wu, Xing-De1
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| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2016-03-01 |
| 卷号 | 109页码:155-161 |
| 关键词 | Lycopodium obscurum L. Lycopodium alkaloids Obscurumines H-P Anti-AChE activity Immunosuppressive activity |
| 英文摘要 | Seven new fawcettimine-type (1-7) and two new lycopodine-type (8 and 9) Lycopodium alkaloids, as well as 10 known compounds, were isolated from the club moss, Lycopodium obscurum L The structures of obscurumines H-P (1-9) were determined based on high-resolution MS and 1D and 2D NMR data. Compounds 1 and 2 include a new skeleton that is formed via the linkage of C-9-N-2', which is "rarely present in Lycopodium alkaloids. The in vitro acetylcholinesterase (AChE) inhibitory activity assay showed that 5 exhibited weak anti-AChE activity with an IC50 value of 81.0 mu M. Compound 8 exhibited inhibition of the secretion of IL-2 in phytohemagglutinin (PHA) and phorbol myristate acetate (PMA) stimulated Jurkat cells, and the IC50 value was 17.2 mu M. (C) 2015 Elsevier B.V. All rights reserved. |
| 类目[WOS] | Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 研究领域[WOS] | Pharmacology & Pharmacy |
| 关键词[WOS] | JAPONICUM |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000372685400024 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/26188]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China 2.Yunnan Agr Univ, Coll Basic Sci & Informat Engn, Kuming 6540201, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiang, Wei-Wei,Liu, Yu-Chen,Zhang, Zhi-Jun,et al. Obscurumines H-P, new Lycopodium alkaloids from the club moss Lycopodium obscurum[J]. FITOTERAPIA,2016,109:155-161. |
| APA | Jiang, Wei-Wei.,Liu, Yu-Chen.,Zhang, Zhi-Jun.,Liu, Yan-Chun.,He, Juan.,...&Zhao, Qin-Shi.(2016).Obscurumines H-P, new Lycopodium alkaloids from the club moss Lycopodium obscurum.FITOTERAPIA,109,155-161. |
| MLA | Jiang, Wei-Wei,et al."Obscurumines H-P, new Lycopodium alkaloids from the club moss Lycopodium obscurum".FITOTERAPIA 109(2016):155-161. |
入库方式： OAI收割
来源：昆明植物研究所
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