Synthesis, Neuro-protection and Anti-cancer Activities of Simple Isatin Mannich and Schiff Bases
文献类型：期刊论文
| 作者 | Chen, Gang1,2; Ning, Yang1; Zhao, Wei1; Zhang, Yanqiu1; Zhang, Yu2 ; Hao, Xiaojiang2,3,4; Wang, Ye3,4; Mu, Shuzhen3,4
|
| 刊名 | LETTERS IN DRUG DESIGN & DISCOVERY
 |
| 出版日期 | 2016 |
| 卷号 | 13期号:5页码:395-400 |
| 关键词 | Isatin mannich base schiff base synthesis neuro-protection anti-tumor |
| 英文摘要 | The study of isatin, as well as its kind of derivatives, has become a hot topic for a long time. To explore the new compounds and bioactivities, in this work, a series of simple isatin Mannich and Schiff bases was synthesized through the condensation reaction. The structures of these synthesized compounds were characterized using NMR and MS. Furthermore, structure of one of these compounds (IMS-4) was studied by using single crystal X-ray diffraction. Then the anti-tumor and neuro-protection activities of these compounds were evaluated. The results showed that several compounds show protection activity on the PC12 cells apoptosis induced by H2O2, which are more effective than that of (+/-) alpha-Tocophreol (VE). Besides, some compounds also show anti-tumor activity against A549 and P388 cell lines more potent than that of isatin. |
| 类目[WOS] | Chemistry, Medicinal |
| 研究领域[WOS] | Pharmacology & Pharmacy |
| 关键词[WOS] | DERIVATIVES ; INHIBITORS ; ANALOGS ; DESIGN ; POTENT ; AGENTS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000374883700006 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/26222]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Xian Shiyou Univ, Coll Chem & Chem Engn, Xian 701165, Shaanxi, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China 3.Key Lab Chem Nat Prod Guizhou Prov, Guiyang 550002, Peoples R China 4.Chinese Acad Sci, Guiyang 550002, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Gang,Ning, Yang,Zhao, Wei,et al. Synthesis, Neuro-protection and Anti-cancer Activities of Simple Isatin Mannich and Schiff Bases[J]. LETTERS IN DRUG DESIGN & DISCOVERY,2016,13(5):395-400. |
| APA | Chen, Gang.,Ning, Yang.,Zhao, Wei.,Zhang, Yanqiu.,Zhang, Yu.,...&Mu, Shuzhen.(2016).Synthesis, Neuro-protection and Anti-cancer Activities of Simple Isatin Mannich and Schiff Bases.LETTERS IN DRUG DESIGN & DISCOVERY,13(5),395-400. |
| MLA | Chen, Gang,et al."Synthesis, Neuro-protection and Anti-cancer Activities of Simple Isatin Mannich and Schiff Bases".LETTERS IN DRUG DESIGN & DISCOVERY 13.5(2016):395-400. |
入库方式： OAI收割
来源：昆明植物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。