New Cytotoxic Tigliane Diterpenoids from Croton caudatus
文献类型：期刊论文
| 作者 | Chen, Ying-Ying1,2; Yang, Kun-Xian3; Yang, Xing-Wei1 ; Khan, Afsar1,4; Liu, Lu1,2; Wang, Bei1,2; Zhao, Yun-Li1; Liu, Ya-Ping1; Li, Yan1; Luo, Xiao-Dong1
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| 刊名 | PLANTA MEDICA
 |
| 出版日期 | 2016-05-01 |
| 卷号 | 82期号:8页码:729-733 |
| 关键词 | Croton caudatus Euphorbiaceae tigliane diterpenoid cytotoxic activity |
| 英文摘要 | Three new tigliane-type diterpenoids were isolated from the methanolic extract of the twigs and leaves of Croton caudatus, trivially named crotusins A-C (1-3). The structures of compounds 1-3 were elucidated on the basis of extensive spectral methods. These new compounds were highly oxygenated and heavily substituted. Cytotoxic activity against five human tumor cell lines was assessed for compounds 1-3 of which compound 3 showed significant inhibitory activity with IC50 values ranging from 0.49 to 4.19 mu M against these cells, while crotusins A and B exhibited moderate activity. |
| 类目[WOS] | Plant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy |
| 研究领域[WOS] | Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine |
| 关键词[WOS] | CHIKUNGUNYA VIRUS-REPLICATION ; CLERODANE DITERPENOIDS ; PHORBOL ; ESTERS ; PROSTRATIN ; ACTIVATION ; INHIBITORS ; POTENT ; LEAVES ; HIV-1 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000377703700008 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/26282]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, 132 Lanhei Rd, Kunming 650201, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.First People Hosp Yunnan Prov, Kunming, Peoples R China 4.COMSATS Inst Informat Technol, Dept Chem, Abbottabad, Pakistan |
| 推荐引用方式 GB/T 7714 | Chen, Ying-Ying,Yang, Kun-Xian,Yang, Xing-Wei,et al. New Cytotoxic Tigliane Diterpenoids from Croton caudatus[J]. PLANTA MEDICA,2016,82(8):729-733. |
| APA | Chen, Ying-Ying.,Yang, Kun-Xian.,Yang, Xing-Wei.,Khan, Afsar.,Liu, Lu.,...&Luo, Xiao-Dong.(2016).New Cytotoxic Tigliane Diterpenoids from Croton caudatus.PLANTA MEDICA,82(8),729-733. |
| MLA | Chen, Ying-Ying,et al."New Cytotoxic Tigliane Diterpenoids from Croton caudatus".PLANTA MEDICA 82.8(2016):729-733. |
入库方式： OAI收割
来源：昆明植物研究所
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