Bavachinin, as a novel natural pan-PPAR agonist, exhibits unique synergistic effects with synthetic PPAR-gamma and PPAR-alpha agonists on carbohydrate and lipid metabolism in db/db and diet-induced obese mice
文献类型：期刊论文
| 作者 | Feng, Li1,2; Luo, Huan3; Xu, Zhijian4; Yang, Zhuo4; Du, Guoxin1; Zhang, Yu2 ; Yu, Lijing2; Hu, Kaifeng3; Zhu, Weiliang4; Tong, Qingchun5
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| 刊名 | DIABETOLOGIA
 |
| 出版日期 | 2016-06-01 |
| 卷号 | 59期号:6页码:1276-1286 |
| 关键词 | Alternative binding site Bavachinin Canonical ligand-binding pocket Carbohydrate metabolism Lipid metabolism Pan-PPAR agonist Synergistic effects |
| 英文摘要 | Aims/hypothesis Pan-peroxisome proliferator-activated receptor (PPAR) agonists have long been sought as therapeutics against the metabolic syndrome, but current PPAR agonists show limited efficacy and adverse effects. Natural herbs provide a structurally untapped resource to prevent and treat complicated metabolic syndrome. |
| 类目[WOS] | Endocrinology & Metabolism |
| 研究领域[WOS] | Endocrinology & Metabolism |
| 关键词[WOS] | PROLIFERATOR-ACTIVATED RECEPTORS ; PEROXISOME PROLIFERATOR ; INSULIN-RESISTANCE ; NUCLEAR RECEPTOR ; DELTA ; BEZAFIBRATE ; LIGAND ; PHOSPHORYLATION ; ROSIGLITAZONE ; DYSLIPIDEMIA |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000378048500026 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/26290]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Shanghai Univ Tradit Chinese Med, Sch Pharm, Dept TCM Chem, 1200 Cailun Rd, Shanghai 201203, Peoples R China 2.Shanghai Univ Tradit Chinese Med, Lab Drug Discovery, Sch Pharm, 1200 Cailun Rd, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, Drug Discovery & Design Ctr, CAS Key Lab Membrane Res, Shanghai 200031, Peoples R China 5.Univ Texas Hlth Sci Ctr Houston, Inst Mol Med, Brown Fdn, Houston, TX 77030 USA |
| 推荐引用方式 GB/T 7714 | Feng, Li,Luo, Huan,Xu, Zhijian,et al. Bavachinin, as a novel natural pan-PPAR agonist, exhibits unique synergistic effects with synthetic PPAR-gamma and PPAR-alpha agonists on carbohydrate and lipid metabolism in db/db and diet-induced obese mice[J]. DIABETOLOGIA,2016,59(6):1276-1286. |
| APA | Feng, Li.,Luo, Huan.,Xu, Zhijian.,Yang, Zhuo.,Du, Guoxin.,...&Li, Yiming.(2016).Bavachinin, as a novel natural pan-PPAR agonist, exhibits unique synergistic effects with synthetic PPAR-gamma and PPAR-alpha agonists on carbohydrate and lipid metabolism in db/db and diet-induced obese mice.DIABETOLOGIA,59(6),1276-1286. |
| MLA | Feng, Li,et al."Bavachinin, as a novel natural pan-PPAR agonist, exhibits unique synergistic effects with synthetic PPAR-gamma and PPAR-alpha agonists on carbohydrate and lipid metabolism in db/db and diet-induced obese mice".DIABETOLOGIA 59.6(2016):1276-1286. |
入库方式： OAI收割
来源：昆明植物研究所
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