Pepluane and Paraliane Diterpenoids from Euphorbia peplus with Potential Anti-inflammatory Activity
文献类型：期刊论文
| 作者 | Wan, Luo-Sheng1; Chu, Rui1,2; Peng, Xing-Rong1; Zhu, Guo-Lei1,2; Yu, Mu-Yuan1,2 ; Li, Lei1,2; Zhou, Lin1; Lu, Shuang-Yang1,2; Dong, Jin-Run1,2; Zhang, Zhi-Run1
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| 刊名 | JOURNAL OF NATURAL PRODUCTS
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| 出版日期 | 2016-06-01 |
| 卷号 | 79期号:6页码:1628-1634 |
| 英文摘要 | Twelve new diterpenoids based on two rare skeletal types, namely, paralianones A-D (1-4) and pepluanols A-H (5-12), along with five known compounds, were isolated from an acetone extract of Euphorbia peplus. Their structures were proposed based on 1D and 2D NMR spectroscopic data analysis. These diterpenoids were evaluated for potential anti-inflammatory activity in a lipopolysaccharidestimulated mouse macrophage cellular model. Compounds 3, 4, 11, 13, and 16 displayed moderate inhibitory effects on NO inhibition, with IC50 values ranging from 29.9 to 38.3 mu M. |
| 类目[WOS] | Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
| 研究领域[WOS] | Plant Sciences ; Pharmacology & Pharmacy |
| 关键词[WOS] | INGENOL MEBUTATE ; DISCOVERY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000378758200018 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/26297]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wan, Luo-Sheng,Chu, Rui,Peng, Xing-Rong,et al. Pepluane and Paraliane Diterpenoids from Euphorbia peplus with Potential Anti-inflammatory Activity[J]. JOURNAL OF NATURAL PRODUCTS,2016,79(6):1628-1634. |
| APA | Wan, Luo-Sheng.,Chu, Rui.,Peng, Xing-Rong.,Zhu, Guo-Lei.,Yu, Mu-Yuan.,...&Qiu, Ming-Hua.(2016).Pepluane and Paraliane Diterpenoids from Euphorbia peplus with Potential Anti-inflammatory Activity.JOURNAL OF NATURAL PRODUCTS,79(6),1628-1634. |
| MLA | Wan, Luo-Sheng,et al."Pepluane and Paraliane Diterpenoids from Euphorbia peplus with Potential Anti-inflammatory Activity".JOURNAL OF NATURAL PRODUCTS 79.6(2016):1628-1634. |
入库方式： OAI收割
来源：昆明植物研究所
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