Miscellaneous meroterpenoids from Ganoderma applanatum
文献类型：期刊论文
| 作者 | Luo, Qi ; Yang, Xiao-Hua; Yang, Zhu-Liang; Tu, Zheng-Chao; Cheng, Yong-Xian
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| 刊名 | TETRAHEDRON
 |
| 出版日期 | 2016-07-28 |
| 卷号 | 72期号:30页码:4564-4574 |
| 关键词 | Ganoderma applanatum Meroterpenoids Alkaloids COX-1/2 |
| 英文摘要 | Twenty-six new meroterpenoids, applanatumols C-Z (1-24), Zl (25) and Z2 (26), and three new alkaloids, ganoapplanatumines A (27), B (28) and epi-ganoapplanatumine B (29), were isolated from the fruiting bodies of Ganoderma applanatum. With exception of 18 and 25, all the other compounds are racemates, Chiral HPLC separation afforded their respective enantiomers. The structures of these isolates including their absolute configurations were assigned by spectroscopic and computational methods. In particular, the structures of 1, 3 and 12 were confirmed by single crystal X-ray diffraction data. Biological activities of all the isolates against COX-1 and COX-2 were evaluated, compound la was found to have COX-2 inhibitory effect with IC50 value of 25.5 mu M. (C) 2016 Elsevier Ltd. All rights reserved. |
| 类目[WOS] | Chemistry, Organic |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | METABOLITES ; LUCIDUM ; INHIBITORS ; LINGZHI ; POTENT |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000380073300012 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/28490]  |
| 专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Luo, Qi,Yang, Xiao-Hua,Yang, Zhu-Liang,et al. Miscellaneous meroterpenoids from Ganoderma applanatum[J]. TETRAHEDRON,2016,72(30):4564-4574. |
| APA | Luo, Qi,Yang, Xiao-Hua,Yang, Zhu-Liang,Tu, Zheng-Chao,&Cheng, Yong-Xian.(2016).Miscellaneous meroterpenoids from Ganoderma applanatum.TETRAHEDRON,72(30),4564-4574. |
| MLA | Luo, Qi,et al."Miscellaneous meroterpenoids from Ganoderma applanatum".TETRAHEDRON 72.30(2016):4564-4574. |
入库方式： OAI收割
来源：昆明植物研究所
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